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HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma

BACKGROUND: Mutations in HBx gene are frequently found in HBV-associated hepatocellular carcinoma (HCC). Activation of hypoxia-inducible factor-1α (HIF-1α) contributes to HCC development and progression. Wild-type HBx has been demonstrated to activate HIF-1α, but the effect of HBx mutations on HIF-1...

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Detalles Bibliográficos
Autores principales:	Liu, L-p, Hu, B-g, Ye, C, Ho, R L K, Chen, G G, Lai, P B S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929872/ https://www.ncbi.nlm.nih.gov/pubmed/24346287 http://dx.doi.org/10.1038/bjc.2013.787

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