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Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis()
Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to central metabolic sensing, partially by acting in leptin receptor (LepRb)-expressi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929908/ https://www.ncbi.nlm.nih.gov/pubmed/24567904 http://dx.doi.org/10.1016/j.molmet.2013.10.004 |