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Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000...

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Autores principales: Aboubakr, Mohamed, Elbadawy, Mohamed, Soliman, Ahmed, El-Hewaity, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930024/
https://www.ncbi.nlm.nih.gov/pubmed/24639869
http://dx.doi.org/10.1155/2014/924706
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author Aboubakr, Mohamed
Elbadawy, Mohamed
Soliman, Ahmed
El-Hewaity, Mohamed
author_facet Aboubakr, Mohamed
Elbadawy, Mohamed
Soliman, Ahmed
El-Hewaity, Mohamed
author_sort Aboubakr, Mohamed
collection PubMed
description This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg·b·wt/day orally for the same period, respectively; Group D behaved as control and received 0.5 mL distilled water orally for the same period. The dams were killed on 20th day of gestation and their fetuses were subjected to morphological, visceral, and skeletal examinations. Norfloxacin significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant. Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy.
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spelling pubmed-39300242014-03-17 Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats Aboubakr, Mohamed Elbadawy, Mohamed Soliman, Ahmed El-Hewaity, Mohamed Adv Pharmacol Sci Research Article This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg·b·wt/day orally for the same period, respectively; Group D behaved as control and received 0.5 mL distilled water orally for the same period. The dams were killed on 20th day of gestation and their fetuses were subjected to morphological, visceral, and skeletal examinations. Norfloxacin significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant. Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy. Hindawi Publishing Corporation 2014 2014-02-03 /pmc/articles/PMC3930024/ /pubmed/24639869 http://dx.doi.org/10.1155/2014/924706 Text en Copyright © 2014 Mohamed Aboubakr et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aboubakr, Mohamed
Elbadawy, Mohamed
Soliman, Ahmed
El-Hewaity, Mohamed
Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
title Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
title_full Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
title_fullStr Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
title_full_unstemmed Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
title_short Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
title_sort embryotoxic and teratogenic effects of norfloxacin in pregnant female albino rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930024/
https://www.ncbi.nlm.nih.gov/pubmed/24639869
http://dx.doi.org/10.1155/2014/924706
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