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Pregnancy Outcome after Varenicline Exposure in the First Trimester

To the best of our knowledge this is the first case report describing exposure to varenicline, an α (4) β (2) nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day un...

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Autores principales: Kaplan, Yusuf Cem, Olgac Dündar, Nihal, Kasap, Burcu, Karadas, Barıs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930087/
https://www.ncbi.nlm.nih.gov/pubmed/24639907
http://dx.doi.org/10.1155/2014/263981
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author Kaplan, Yusuf Cem
Olgac Dündar, Nihal
Kasap, Burcu
Karadas, Barıs
author_facet Kaplan, Yusuf Cem
Olgac Dündar, Nihal
Kasap, Burcu
Karadas, Barıs
author_sort Kaplan, Yusuf Cem
collection PubMed
description To the best of our knowledge this is the first case report describing exposure to varenicline, an α (4) β (2) nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintentionally yet regularly 4 weeks from her last menstrual period. Fetal ultrasound performed at each trimester, detailed anomaly scan, and fetal echocardiography which were performed at the 22nd gestational week showed normal fetal growth with no malformations. The patient delivered a healthy baby at the 38th week of gestation with normal Apgar score and physical examination findings. Age-appropriate physical and neurological development of the child has been observed for 6 months. Although it is not possible to draw definitive conclusions, this case report may contribute to the current available limited data regarding the safety of varenicline use in pregnancy.
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spelling pubmed-39300872014-03-17 Pregnancy Outcome after Varenicline Exposure in the First Trimester Kaplan, Yusuf Cem Olgac Dündar, Nihal Kasap, Burcu Karadas, Barıs Case Rep Obstet Gynecol Case Report To the best of our knowledge this is the first case report describing exposure to varenicline, an α (4) β (2) nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintentionally yet regularly 4 weeks from her last menstrual period. Fetal ultrasound performed at each trimester, detailed anomaly scan, and fetal echocardiography which were performed at the 22nd gestational week showed normal fetal growth with no malformations. The patient delivered a healthy baby at the 38th week of gestation with normal Apgar score and physical examination findings. Age-appropriate physical and neurological development of the child has been observed for 6 months. Although it is not possible to draw definitive conclusions, this case report may contribute to the current available limited data regarding the safety of varenicline use in pregnancy. Hindawi Publishing Corporation 2014 2014-02-03 /pmc/articles/PMC3930087/ /pubmed/24639907 http://dx.doi.org/10.1155/2014/263981 Text en Copyright © 2014 Yusuf Cem Kaplan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kaplan, Yusuf Cem
Olgac Dündar, Nihal
Kasap, Burcu
Karadas, Barıs
Pregnancy Outcome after Varenicline Exposure in the First Trimester
title Pregnancy Outcome after Varenicline Exposure in the First Trimester
title_full Pregnancy Outcome after Varenicline Exposure in the First Trimester
title_fullStr Pregnancy Outcome after Varenicline Exposure in the First Trimester
title_full_unstemmed Pregnancy Outcome after Varenicline Exposure in the First Trimester
title_short Pregnancy Outcome after Varenicline Exposure in the First Trimester
title_sort pregnancy outcome after varenicline exposure in the first trimester
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930087/
https://www.ncbi.nlm.nih.gov/pubmed/24639907
http://dx.doi.org/10.1155/2014/263981
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