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Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials
BACKGROUND: It was reported that 64% of tic disorder patients used complementary and alternative medicine. This review aims to evaluate the efficacy of herbal medicines in treating tic disorders. METHODS: We searched eight databases including MEDLINE and CINAHL from their respective inceptions up to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930107/ https://www.ncbi.nlm.nih.gov/pubmed/24507013 http://dx.doi.org/10.1186/1749-8546-9-6 |
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author | Kim, Yun Hee Son, Chang-Gue Ku, Bon-Cho Lee, Hye Won Lim, Hyun Sook Lee, Myeong Soo |
author_facet | Kim, Yun Hee Son, Chang-Gue Ku, Bon-Cho Lee, Hye Won Lim, Hyun Sook Lee, Myeong Soo |
author_sort | Kim, Yun Hee |
collection | PubMed |
description | BACKGROUND: It was reported that 64% of tic disorder patients used complementary and alternative medicine. This review aims to evaluate the efficacy of herbal medicines in treating tic disorders. METHODS: We searched eight databases including MEDLINE and CINAHL from their respective inceptions up to September 2013. The search terms were related to the concept of “herbal medicine” AND “tic disorder OR Tourette’s syndrome”. We included randomised controlled trials (RCTs) of any type of herbal medicines. We assessed the methodological quality of the trials according to the Cochrane risk of bias criteria. RESULTS: Sixty one studies were identified, and four RCTs met the inclusion criteria. Two types of herbal medicines, Qufeng Zhidong Recipe (QZR) decoction and Ningdong (ND) granules, were used in the included RCTs. All four RCTs had a high risk of bias. Two RCTs tested the effects of QZR on the Yale Global Tic Severity Scale (YGTSS) score and response rate compared with conventional medicine. The meta-analysis showed significant effects of QZR on the YGTSS score with high statistical heterogeneity (n = 142; weighted mean difference: −18.34; 95% confidence interval (CI): −23.07 to −13.60; I(2) = 97%) and the response rate (n = 142; risk ratio: 1.69; 95% CI: 1.39 to 2.06; I(2) = 0%). One RCT compared ND granules with placebo and showed significant effects on the YGTSS score and response rate. The other RCT show significant effects of ND granules plus conventional medicine on the response rate compared with conventional medicine only. CONCLUSION: This systematic review provided first piece of limited meta-analytic evidence for the effectiveness of herbal medicines in improving the symptoms of tic disorders. |
format | Online Article Text |
id | pubmed-3930107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39301072014-02-21 Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials Kim, Yun Hee Son, Chang-Gue Ku, Bon-Cho Lee, Hye Won Lim, Hyun Sook Lee, Myeong Soo Chin Med Review BACKGROUND: It was reported that 64% of tic disorder patients used complementary and alternative medicine. This review aims to evaluate the efficacy of herbal medicines in treating tic disorders. METHODS: We searched eight databases including MEDLINE and CINAHL from their respective inceptions up to September 2013. The search terms were related to the concept of “herbal medicine” AND “tic disorder OR Tourette’s syndrome”. We included randomised controlled trials (RCTs) of any type of herbal medicines. We assessed the methodological quality of the trials according to the Cochrane risk of bias criteria. RESULTS: Sixty one studies were identified, and four RCTs met the inclusion criteria. Two types of herbal medicines, Qufeng Zhidong Recipe (QZR) decoction and Ningdong (ND) granules, were used in the included RCTs. All four RCTs had a high risk of bias. Two RCTs tested the effects of QZR on the Yale Global Tic Severity Scale (YGTSS) score and response rate compared with conventional medicine. The meta-analysis showed significant effects of QZR on the YGTSS score with high statistical heterogeneity (n = 142; weighted mean difference: −18.34; 95% confidence interval (CI): −23.07 to −13.60; I(2) = 97%) and the response rate (n = 142; risk ratio: 1.69; 95% CI: 1.39 to 2.06; I(2) = 0%). One RCT compared ND granules with placebo and showed significant effects on the YGTSS score and response rate. The other RCT show significant effects of ND granules plus conventional medicine on the response rate compared with conventional medicine only. CONCLUSION: This systematic review provided first piece of limited meta-analytic evidence for the effectiveness of herbal medicines in improving the symptoms of tic disorders. BioMed Central 2014-02-07 /pmc/articles/PMC3930107/ /pubmed/24507013 http://dx.doi.org/10.1186/1749-8546-9-6 Text en Copyright © 2014 Kim et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Kim, Yun Hee Son, Chang-Gue Ku, Bon-Cho Lee, Hye Won Lim, Hyun Sook Lee, Myeong Soo Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
title | Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
title_full | Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
title_fullStr | Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
title_full_unstemmed | Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
title_short | Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
title_sort | herbal medicines for treating tic disorders: a systematic review of randomised controlled trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930107/ https://www.ncbi.nlm.nih.gov/pubmed/24507013 http://dx.doi.org/10.1186/1749-8546-9-6 |
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