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A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics

BACKGROUND: The intracranial aneurysm (IA) size has been proved to have impacts on the hemodynamics and can be applied for the prediction of IA rupture risk. Although the relationship between aspect ratio and hemodynamic parameters was investigated using real patients and virtual models, few studies...

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Autores principales: Long, Yunling, Yu, Hongyu, Zhuo, Zhizheng, Zhang, Ying, Wang, Yang, Yang, Xinjian, Li, Haiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930299/
https://www.ncbi.nlm.nih.gov/pubmed/24528952
http://dx.doi.org/10.1186/1475-925X-13-17
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author Long, Yunling
Yu, Hongyu
Zhuo, Zhizheng
Zhang, Ying
Wang, Yang
Yang, Xinjian
Li, Haiyun
author_facet Long, Yunling
Yu, Hongyu
Zhuo, Zhizheng
Zhang, Ying
Wang, Yang
Yang, Xinjian
Li, Haiyun
author_sort Long, Yunling
collection PubMed
description BACKGROUND: The intracranial aneurysm (IA) size has been proved to have impacts on the hemodynamics and can be applied for the prediction of IA rupture risk. Although the relationship between aspect ratio and hemodynamic parameters was investigated using real patients and virtual models, few studies focused on longitudinal experiments of IAs based on patient-specific aneurysm models. We attempted to do longitudinal simulation experiments of IAs by developing a series of scaled models. METHODS: In this work, a novel scaling approach was proposed to create IA models with different aneurysm size ratios (ASRs) defined as IA height divided by average neck diameter from a patient-specific aneurysm model and the relationship between the ASR and hemodynamics was explored based on a simulated longitudinal experiment. Wall shear stress, flow patterns and vessel wall displacement were computed from these models. Pearson correlation analysis was performed to elucidate the relationship between the ASR and wall shear stress. The correlation of the ASR and flow velocity was also computed and analyzed. RESULTS: The experiment results showed that there was a significant increase in IA area exposed to low WSS once the ASR > 0.7, and the flow became slower and the blood was more difficult to flow into the aneurysm as the ASR increased. Meanwhile, the results also indicated that average blood flow velocity and WSS had strongly negative correlations with the ASR (r = −0.938 and −0.925, respectively). A narrower impingement region and a more concentrated inflow jet appeared as the ASR increased, and the large local deformation at aneurysm apex could be found as the ASR >1.7 or 0.7 < the ASR <1.0. CONCLUSION: Hemodynamic characteristics varied with the ASR. Besides, it is helpful to further explore the relationship between morphologies and hemodynamics based on a longitudinal simulation by building a series of patient-specific aneurysm scaled models applying our proposed IA scaling algorithm.
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spelling pubmed-39302992014-03-04 A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics Long, Yunling Yu, Hongyu Zhuo, Zhizheng Zhang, Ying Wang, Yang Yang, Xinjian Li, Haiyun Biomed Eng Online Research BACKGROUND: The intracranial aneurysm (IA) size has been proved to have impacts on the hemodynamics and can be applied for the prediction of IA rupture risk. Although the relationship between aspect ratio and hemodynamic parameters was investigated using real patients and virtual models, few studies focused on longitudinal experiments of IAs based on patient-specific aneurysm models. We attempted to do longitudinal simulation experiments of IAs by developing a series of scaled models. METHODS: In this work, a novel scaling approach was proposed to create IA models with different aneurysm size ratios (ASRs) defined as IA height divided by average neck diameter from a patient-specific aneurysm model and the relationship between the ASR and hemodynamics was explored based on a simulated longitudinal experiment. Wall shear stress, flow patterns and vessel wall displacement were computed from these models. Pearson correlation analysis was performed to elucidate the relationship between the ASR and wall shear stress. The correlation of the ASR and flow velocity was also computed and analyzed. RESULTS: The experiment results showed that there was a significant increase in IA area exposed to low WSS once the ASR > 0.7, and the flow became slower and the blood was more difficult to flow into the aneurysm as the ASR increased. Meanwhile, the results also indicated that average blood flow velocity and WSS had strongly negative correlations with the ASR (r = −0.938 and −0.925, respectively). A narrower impingement region and a more concentrated inflow jet appeared as the ASR increased, and the large local deformation at aneurysm apex could be found as the ASR >1.7 or 0.7 < the ASR <1.0. CONCLUSION: Hemodynamic characteristics varied with the ASR. Besides, it is helpful to further explore the relationship between morphologies and hemodynamics based on a longitudinal simulation by building a series of patient-specific aneurysm scaled models applying our proposed IA scaling algorithm. BioMed Central 2014-02-17 /pmc/articles/PMC3930299/ /pubmed/24528952 http://dx.doi.org/10.1186/1475-925X-13-17 Text en Copyright © 2014 Long et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Long, Yunling
Yu, Hongyu
Zhuo, Zhizheng
Zhang, Ying
Wang, Yang
Yang, Xinjian
Li, Haiyun
A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
title A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
title_full A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
title_fullStr A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
title_full_unstemmed A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
title_short A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
title_sort geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930299/
https://www.ncbi.nlm.nih.gov/pubmed/24528952
http://dx.doi.org/10.1186/1475-925X-13-17
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