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Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice
The activation of epidermal growth factor receptor (EGFR) affects multiple aspects of neural precursor behaviour, including proliferation and migration. Telencephalic precursors acquire EGF responsiveness and upregulate EGFR expression at late stages of development. The events regulating this proces...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Company of Biologists
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930467/ https://www.ncbi.nlm.nih.gov/pubmed/24496615 http://dx.doi.org/10.1242/dev.096131 |
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author | Carrillo-García, Carmen Prochnow, Sebastian Simeonova, Ina K. Strelau, Jens Hölzl-Wenig, Gabriele Mandl, Claudia Unsicker, Klaus von Bohlen und Halbach, Oliver Ciccolini, Francesca |
author_facet | Carrillo-García, Carmen Prochnow, Sebastian Simeonova, Ina K. Strelau, Jens Hölzl-Wenig, Gabriele Mandl, Claudia Unsicker, Klaus von Bohlen und Halbach, Oliver Ciccolini, Francesca |
author_sort | Carrillo-García, Carmen |
collection | PubMed |
description | The activation of epidermal growth factor receptor (EGFR) affects multiple aspects of neural precursor behaviour, including proliferation and migration. Telencephalic precursors acquire EGF responsiveness and upregulate EGFR expression at late stages of development. The events regulating this process and its significance are still unclear. We here show that in the developing and postnatal hippocampus (HP), growth/differentiation factor (GDF) 15 and EGFR are co-expressed in primitive precursors as well as in more differentiated cells. We also provide evidence that GDF15 promotes responsiveness to EGF and EGFR expression in hippocampal precursors through a mechanism that requires active CXC chemokine receptor (CXCR) 4. Besides EGFR expression, GDF15 ablation also leads to decreased proliferation and migration. In particular, lack of GDF15 impairs both processes in the cornu ammonis (CA) 1 and only proliferation in the dentate gyrus (DG). Importantly, migration and proliferation in the mutant HP were altered only perinatally, when EGFR expression was also affected. These data suggest that GDF15 regulates migration and proliferation by promoting EGFR signalling in the perinatal HP and represent a first description of a functional role for GDF15 in the developing telencephalon. |
format | Online Article Text |
id | pubmed-3930467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Company of Biologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-39304672014-02-25 Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice Carrillo-García, Carmen Prochnow, Sebastian Simeonova, Ina K. Strelau, Jens Hölzl-Wenig, Gabriele Mandl, Claudia Unsicker, Klaus von Bohlen und Halbach, Oliver Ciccolini, Francesca Development Stem Cells and Regeneration The activation of epidermal growth factor receptor (EGFR) affects multiple aspects of neural precursor behaviour, including proliferation and migration. Telencephalic precursors acquire EGF responsiveness and upregulate EGFR expression at late stages of development. The events regulating this process and its significance are still unclear. We here show that in the developing and postnatal hippocampus (HP), growth/differentiation factor (GDF) 15 and EGFR are co-expressed in primitive precursors as well as in more differentiated cells. We also provide evidence that GDF15 promotes responsiveness to EGF and EGFR expression in hippocampal precursors through a mechanism that requires active CXC chemokine receptor (CXCR) 4. Besides EGFR expression, GDF15 ablation also leads to decreased proliferation and migration. In particular, lack of GDF15 impairs both processes in the cornu ammonis (CA) 1 and only proliferation in the dentate gyrus (DG). Importantly, migration and proliferation in the mutant HP were altered only perinatally, when EGFR expression was also affected. These data suggest that GDF15 regulates migration and proliferation by promoting EGFR signalling in the perinatal HP and represent a first description of a functional role for GDF15 in the developing telencephalon. Company of Biologists 2014-02-15 /pmc/articles/PMC3930467/ /pubmed/24496615 http://dx.doi.org/10.1242/dev.096131 Text en © 2014. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by-nc-sa/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Stem Cells and Regeneration Carrillo-García, Carmen Prochnow, Sebastian Simeonova, Ina K. Strelau, Jens Hölzl-Wenig, Gabriele Mandl, Claudia Unsicker, Klaus von Bohlen und Halbach, Oliver Ciccolini, Francesca Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
title | Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
title_full | Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
title_fullStr | Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
title_full_unstemmed | Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
title_short | Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
title_sort | growth/differentiation factor 15 promotes egfr signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice |
topic | Stem Cells and Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930467/ https://www.ncbi.nlm.nih.gov/pubmed/24496615 http://dx.doi.org/10.1242/dev.096131 |
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