Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the dev...

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Detalles Bibliográficos
Autores principales: Gardner, Christina L., Hritz, Jozef, Sun, Chengqun, Vanlandingham, Dana L., Song, Timothy Y., Ghedin, Elodie, Higgs, Stephen, Klimstra, William B., Ryman, Kate D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930508/
https://www.ncbi.nlm.nih.gov/pubmed/24587470
http://dx.doi.org/10.1371/journal.pntd.0002719

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