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Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP ortholog) play a key role in DNA damage checkpoint responses in budding yeast. Previous studies have established the model in which Ddc1, a subunit of the checkpoint clamp, and Dpb11, related to TopBP1, activate Mec1 directly and con...

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Detalles Bibliográficos
Autores principales:	Bandhu, Amitava, Kang, John, Fukunaga, Kenzo, Goto, Greicy, Sugimoto, Katsunori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930518/ https://www.ncbi.nlm.nih.gov/pubmed/24586187 http://dx.doi.org/10.1371/journal.pgen.1004136

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