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Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis
In mammals, the corpus luteum (CL) is an essential endocrine gland for the establishment and maintenance of pregnancy. If pregnancy is not established, the CL regresses and disappears rapidly from the ovary. A possible explanation for the rapid disappearance of the CL is that luteal cells are transp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930584/ https://www.ncbi.nlm.nih.gov/pubmed/24586455 http://dx.doi.org/10.1371/journal.pone.0088953 |
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author | Abe, Hironori Al-zi’abi, Mohamad Omar Sekizawa, Fumio Acosta, Tomas J. Skarzynski, Dariusz J. Okuda, Kiyoshi |
author_facet | Abe, Hironori Al-zi’abi, Mohamad Omar Sekizawa, Fumio Acosta, Tomas J. Skarzynski, Dariusz J. Okuda, Kiyoshi |
author_sort | Abe, Hironori |
collection | PubMed |
description | In mammals, the corpus luteum (CL) is an essential endocrine gland for the establishment and maintenance of pregnancy. If pregnancy is not established, the CL regresses and disappears rapidly from the ovary. A possible explanation for the rapid disappearance of the CL is that luteal cells are transported from the ovary via lymphatic vessels. Here, we report the presence of cells positive for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme involved in progesterone synthesis, in the lumen of lymphatic vessels at the regressing luteal stage and in the lymphatic fluid collected from the ovarian pedicle ipsilateral to the regressing CL. The 3β-HSD positive cells were alive and contained lipid droplets. The 3β-HSD positive cells in the lymphatic fluid were most abundant at days 22–24 after ovulation. These findings show that live steroidogenic cells are in the lymphatic vessels drained from the CL. The outflow of steroidogenic cells starts at the regressing luteal stage and continues after next ovulation. The overall findings suggest that the complete disappearance of the CL during luteolysis is involved in the outflow of luteal cells from the CL via ovarian lymphatic vessels. |
format | Online Article Text |
id | pubmed-3930584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39305842014-02-25 Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis Abe, Hironori Al-zi’abi, Mohamad Omar Sekizawa, Fumio Acosta, Tomas J. Skarzynski, Dariusz J. Okuda, Kiyoshi PLoS One Research Article In mammals, the corpus luteum (CL) is an essential endocrine gland for the establishment and maintenance of pregnancy. If pregnancy is not established, the CL regresses and disappears rapidly from the ovary. A possible explanation for the rapid disappearance of the CL is that luteal cells are transported from the ovary via lymphatic vessels. Here, we report the presence of cells positive for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme involved in progesterone synthesis, in the lumen of lymphatic vessels at the regressing luteal stage and in the lymphatic fluid collected from the ovarian pedicle ipsilateral to the regressing CL. The 3β-HSD positive cells were alive and contained lipid droplets. The 3β-HSD positive cells in the lymphatic fluid were most abundant at days 22–24 after ovulation. These findings show that live steroidogenic cells are in the lymphatic vessels drained from the CL. The outflow of steroidogenic cells starts at the regressing luteal stage and continues after next ovulation. The overall findings suggest that the complete disappearance of the CL during luteolysis is involved in the outflow of luteal cells from the CL via ovarian lymphatic vessels. Public Library of Science 2014-02-20 /pmc/articles/PMC3930584/ /pubmed/24586455 http://dx.doi.org/10.1371/journal.pone.0088953 Text en © 2014 Abe et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Abe, Hironori Al-zi’abi, Mohamad Omar Sekizawa, Fumio Acosta, Tomas J. Skarzynski, Dariusz J. Okuda, Kiyoshi Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis |
title | Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis |
title_full | Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis |
title_fullStr | Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis |
title_full_unstemmed | Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis |
title_short | Lymphatic Involvement in the Disappearance of Steroidogenic Cells from the Corpus Luteum during Luteolysis |
title_sort | lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930584/ https://www.ncbi.nlm.nih.gov/pubmed/24586455 http://dx.doi.org/10.1371/journal.pone.0088953 |
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