IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma

BACKGROUND: Recent studies have identified prevalent isocitrate dehydrogenase 1 (IDH1) codon 132 mutations (p.R132) in gliomas and acute myeloid leukemia (AML). The IDH1 mutations lead to a loss of its normal enzymatic activity and acquisition of neomorphic activity in production of α-ketoglutarate...

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Detalles Bibliográficos
Autores principales: Lu, Jun, Zou, Yang, Xu, Ling, Yang, Run-Xiang, Fan, Yu, Zhang, Wen, Yu, Dandan, Yao, Yong-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930585/
https://www.ncbi.nlm.nih.gov/pubmed/24531386
http://dx.doi.org/10.12659/MSM.889891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930585/
https://www.ncbi.nlm.nih.gov/pubmed/24531386
http://dx.doi.org/10.12659/MSM.889891

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