Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest derived cell line

Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF) is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established...

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Detalles Bibliográficos
Autores principales: DeWitt, John, Ochoa, Vanessa, Urschitz, Johann, Elston, Marlee, Moisyadi, Stefan, Nishi, Rae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930615/
https://www.ncbi.nlm.nih.gov/pubmed/23455321
http://dx.doi.org/10.1038/onc.2013.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930615/
https://www.ncbi.nlm.nih.gov/pubmed/23455321
http://dx.doi.org/10.1038/onc.2013.39

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