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Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest derived cell line
Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF) is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930615/ https://www.ncbi.nlm.nih.gov/pubmed/23455321 http://dx.doi.org/10.1038/onc.2013.39 |