Cargando…
Effect of Darapladib Treatment on Endarterectomy Carotid Plaque Lipoprotein-Associated Phospholipase A(2) Activity: A Randomized, Controlled Trial
BACKGROUND: The aim of this study was to assess the effects of darapladib, a selective oral investigational lipoprotein-associated phospholipase A(2) inhibitor, on both plasma and plaque lipoprotein-associated phospholipase A(2) activity. METHODS: Patients undergoing elective carotid endarterectomy...
Autores principales: | Johnson, Joel L., Shi, Yi, Snipes, Rose, Janmohamed, Salim, Rolfe, Timothy E., Davis, Bill, Postle, Anthony, Macphee, Colin H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930668/ https://www.ncbi.nlm.nih.gov/pubmed/24586490 http://dx.doi.org/10.1371/journal.pone.0089034 |
Ejemplares similares
-
Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis
por: Zhang, Juan, et al.
Publicado: (2016) -
Active site competition is the mechanism for the inhibition of lipoprotein-associated phospholipase A(2) by detergent micelles or lipoproteins and for the efficacy reduction of darapladib
por: Zhuo, Shaoqiu, et al.
Publicado: (2020) -
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism
por: Oh, Mihee, et al.
Publicado: (2023) -
Carotid plaque volume in patients undergoing carotid endarterectomy
por: Ball, S., et al.
Publicado: (2018) -
Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
por: Rerkasem, Kittipan, et al.
Publicado: (2008)