Cargando…

Comparison of the ‘Chemical’ and ‘Structural’ Approaches to the Optimization of the Thrombin-Binding Aptamer

Noncanonically structured DNA aptamers to thrombin were examined. Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer. These approaches are chemical modification and the addition of a duplex module to the aptamer core...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tatarinova, Olga, Tsvetkov, Vladimir, Basmanov, Dmitry, Barinov, Nikolay, Smirnov, Igor, Timofeev, Edward, Kaluzhny, Dmitry, Chuvilin, Andrey, Klinov, Dmitry, Varizhuk, Anna, Pozmogova, Galina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930721/ https://www.ncbi.nlm.nih.gov/pubmed/24586736 http://dx.doi.org/10.1371/journal.pone.0089383

Ejemplares similares

A Universal Base in a Specific Role: Tuning up a Thrombin Aptamer with 5-Nitroindole
por: Tsvetkov, Vladimir B., et al.
Publicado: (2015)

Spontaneous DNA Synapsis by Forming Noncanonical Intermolecular Structures
por: Severov, Viacheslav, et al.
Publicado: (2022)

Data on secondary structures and ligand interactions of G-rich oligonucleotides that defy the classical formula for G4 motifs
por: Vlasenok, Maria, et al.
Publicado: (2017)

Anticoagulant Oligonucleotide–Peptide Conjugates: Identification of Thrombin Aptamer Conjugates with Improved Characteristics
por: Tsvetkov, Vladimir B., et al.
Publicado: (2022)

Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer
por: Kolganova, Natalia A., et al.
Publicado: (2023)

The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer
por: Varizhuk, Irina V., et al.
Publicado: (2023)

Polymorphism of G4 associates: from stacks to wires via interlocks
por: Varizhuk, Anna M, et al.
Publicado: (2018)

Data set on G4 DNA interactions with human proteins
por: Vlasenok, M., et al.
Publicado: (2018)

Efficient silica synthesis from tetra(glycerol)orthosilicate with cathepsin- and silicatein-like proteins
por: Povarova, Natalia V., et al.
Publicado: (2018)

A Solution to the Common Problem of the Synthesis and Applications of Hexachlorofluorescein Labeled Oligonucleotides
por: Chuvilin, Andrey N., et al.
Publicado: (2016)

The systematic approach to describing conformational rearrangements in G-quadruplexes
por: Tsvetkov, Vladimir, et al.
Publicado: (2016)

Stable Enzymatic Nanoparticles from Nucleases, Proteases, Lipase and Antioxidant Proteins with Substrate-Binding and Catalytic Properties
por: Morozova, Olga V., et al.
Publicado: (2023)

Protein nanoparticles with ligand-binding and enzymatic activities
por: Morozova, Olga V, et al.
Publicado: (2018)

Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12
por: Smirnov, Igor, et al.
Publicado: (2021)

Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding
por: Kirillova, Yuliya, et al.
Publicado: (2015)

EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus
por: Tsvetkov, Vladimir, et al.
Publicado: (2021)

Features of DNA–Montmorillonite Binding Visualized by Atomic Force Microscopy
por: Kraevsky, Sergey V., et al.
Publicado: (2023)

Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core
por: Svetlova, Julia, et al.
Publicado: (2021)

DNA i-Motifs With Guanidino-i-Clamp Residues: The Counterplay Between Kinetics and Thermodynamics and Implications for the Design of pH Sensors
por: Tsvetkov, Vladimir B., et al.
Publicado: (2019)

Disordering of Human Telomeric G-Quadruplex with Novel Antiproliferative Anthrathiophenedione
por: Kaluzhny, Dmitry, et al.
Publicado: (2011)

Aureolic Acid Group of Agents as Potential Antituberculosis Drugs
por: Bespyatykh, Julia, et al.
Publicado: (2020)

The Evaluation of Pharmacodynamics and Pharmacokinetics of Anti-thrombin DNA Aptamer RA-36
por: Zavyalova, Elena, et al.
Publicado: (2017)

DNA modification of live cell surface
por: Borisenko, Grigory G., et al.
Publicado: (2009)

Evaluation of Antithrombotic Activity of Thrombin DNA Aptamers by a Murine Thrombosis Model
por: Zavyalova, Elena, et al.
Publicado: (2014)

Targeting of Silver Cations, Silver-Cystine Complexes, Ag Nanoclusters, and Nanoparticles towards SARS-CoV-2 RNA and Recombinant Virion Proteins
por: Morozova, Olga V., et al.
Publicado: (2022)

The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors
por: Sizova, Svetlana, et al.
Publicado: (2021)

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity
por: Dolot, Rafal, et al.
Publicado: (2018)

i-Clamp phenoxazine for the fine tuning of DNA i-motif stability
por: Tsvetkov, Vladimir B, et al.
Publicado: (2018)

Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)
por: Valsangkar, Vibhav, et al.
Publicado: (2021)

Anomalous Laterally Stressed Kinetically Trapped DNA Surface Conformations
por: Prokhorov, Valery V., et al.
Publicado: (2021)

The miscibility and spatial distribution of the components in electrospun polymer–protein mats
por: Pavlova, Elizaveta, et al.
Publicado: (2020)

Biodistribution of Fluorescent Albumin Nanoparticles among Organs of Laboratory Animals after Intranasal and Peroral Administration
por: Morozova, Olga, et al.
Publicado: (2023)

Thermoelectric Behavior of BaZr(0.9)Y(0.1)O(3−d) Proton Conducting Electrolyte
por: Tsvetkov, Dmitry, et al.
Publicado: (2019)

DNA Aptamers for the Characterization of Histological Structure of Lung Adenocarcinoma
por: Zamay, Galina S., et al.
Publicado: (2017)

Thrombin–aptamer recognition: a revealed ambiguity
por: Russo Krauss, Irene, et al.
Publicado: (2011)

Aptamer Based Microsphere Biosensor for Thrombin Detection
por: Zhu, Hongying, et al.
Publicado: (2006)

Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand
por: Kaluzhny, Dmitry N., et al.
Publicado: (2011)

Wetting of electrospun nylon-11 fibers and mats
por: Bagrov, Dmitry, et al.
Publicado: (2021)

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
por: Russo Krauss, Irene, et al.
Publicado: (2012)

Taq-Polymerase Stop Assay to Determine Target Selectivity of G4 Ligands in Native Promoter Sequences of MYC, TERT, and KIT Oncogenes
por: Chashchina, Galina V., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_258h757g5q1boek9dqe9a4pscf