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Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder
INTRODUCTION: Mania is associated with increased activity, whereas psychomotor retardation is often found in bipolar depression. Actigraphy is a promising tool for monitoring phase shifts and changes following treatment in bipolar disorder. The aim of this study was to compare recordings of motor ac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930750/ https://www.ncbi.nlm.nih.gov/pubmed/24586883 http://dx.doi.org/10.1371/journal.pone.0089574 |
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author | Krane-Gartiser, Karoline Henriksen, Tone Elise Gjotterud Morken, Gunnar Vaaler, Arne Fasmer, Ole Bernt |
author_facet | Krane-Gartiser, Karoline Henriksen, Tone Elise Gjotterud Morken, Gunnar Vaaler, Arne Fasmer, Ole Bernt |
author_sort | Krane-Gartiser, Karoline |
collection | PubMed |
description | INTRODUCTION: Mania is associated with increased activity, whereas psychomotor retardation is often found in bipolar depression. Actigraphy is a promising tool for monitoring phase shifts and changes following treatment in bipolar disorder. The aim of this study was to compare recordings of motor activity in mania, bipolar depression and healthy controls, using linear and nonlinear analytical methods. MATERIALS AND METHODS: Recordings from 18 acutely hospitalized inpatients with mania were compared to 12 recordings from bipolar depression inpatients and 28 healthy controls. 24-hour actigraphy recordings and 64-minute periods of continuous motor activity in the morning and evening were analyzed. Mean activity and several measures of variability and complexity were calculated. RESULTS: Patients with depression had a lower mean activity level compared to controls, but higher variability shown by increased standard deviation (SD) and root mean square successive difference (RMSSD) over 24 hours and in the active morning period. The patients with mania had lower first lag autocorrelation compared to controls, and Fourier analysis showed higher variance in the high frequency part of the spectrum corresponding to the period from 2–8 minutes. Both patient groups had a higher RMSSD/SD ratio compared to controls. In patients with mania we found an increased complexity of time series in the active morning period, compared to patients with depression. The findings in the patients with mania are similar to previous findings in patients with schizophrenia and healthy individuals treated with a glutamatergic antagonist. CONCLUSION: We have found distinctly different activity patterns in hospitalized patients with bipolar disorder in episodes of mania and depression, assessed by actigraphy and analyzed with linear and nonlinear mathematical methods, as well as clear differences between the patients and healthy comparison subjects. |
format | Online Article Text |
id | pubmed-3930750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39307502014-02-25 Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder Krane-Gartiser, Karoline Henriksen, Tone Elise Gjotterud Morken, Gunnar Vaaler, Arne Fasmer, Ole Bernt PLoS One Research Article INTRODUCTION: Mania is associated with increased activity, whereas psychomotor retardation is often found in bipolar depression. Actigraphy is a promising tool for monitoring phase shifts and changes following treatment in bipolar disorder. The aim of this study was to compare recordings of motor activity in mania, bipolar depression and healthy controls, using linear and nonlinear analytical methods. MATERIALS AND METHODS: Recordings from 18 acutely hospitalized inpatients with mania were compared to 12 recordings from bipolar depression inpatients and 28 healthy controls. 24-hour actigraphy recordings and 64-minute periods of continuous motor activity in the morning and evening were analyzed. Mean activity and several measures of variability and complexity were calculated. RESULTS: Patients with depression had a lower mean activity level compared to controls, but higher variability shown by increased standard deviation (SD) and root mean square successive difference (RMSSD) over 24 hours and in the active morning period. The patients with mania had lower first lag autocorrelation compared to controls, and Fourier analysis showed higher variance in the high frequency part of the spectrum corresponding to the period from 2–8 minutes. Both patient groups had a higher RMSSD/SD ratio compared to controls. In patients with mania we found an increased complexity of time series in the active morning period, compared to patients with depression. The findings in the patients with mania are similar to previous findings in patients with schizophrenia and healthy individuals treated with a glutamatergic antagonist. CONCLUSION: We have found distinctly different activity patterns in hospitalized patients with bipolar disorder in episodes of mania and depression, assessed by actigraphy and analyzed with linear and nonlinear mathematical methods, as well as clear differences between the patients and healthy comparison subjects. Public Library of Science 2014-02-20 /pmc/articles/PMC3930750/ /pubmed/24586883 http://dx.doi.org/10.1371/journal.pone.0089574 Text en © 2014 Krane-Gartiser et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Krane-Gartiser, Karoline Henriksen, Tone Elise Gjotterud Morken, Gunnar Vaaler, Arne Fasmer, Ole Bernt Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder |
title | Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder |
title_full | Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder |
title_fullStr | Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder |
title_full_unstemmed | Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder |
title_short | Actigraphic Assessment of Motor Activity in Acutely Admitted Inpatients with Bipolar Disorder |
title_sort | actigraphic assessment of motor activity in acutely admitted inpatients with bipolar disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930750/ https://www.ncbi.nlm.nih.gov/pubmed/24586883 http://dx.doi.org/10.1371/journal.pone.0089574 |
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