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The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?

BACKGROUND: Many markers have been proposed for CVD risk assessment in dialysis population. Apelin is a peptide that has roles in cardiovascular functions and volume regulation namely vasodilation, decreased blood pressure (BP), positive inotropic effect and inhibition of antidiuretic hormone releas...

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Autores principales: Karadag, Serhat, Ozturk, Savas, Gursu, Meltem, Gurdal, Ahmet, Basinoglu, Filiz, Yigit, Servet, Aydin, Zeki, Uzun, Sami, Sumnu, Abdullah, Oflaz, Huseyin, Kazancioglu, Rumeyza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930824/
https://www.ncbi.nlm.nih.gov/pubmed/24433492
http://dx.doi.org/10.1186/1471-2369-15-18
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author Karadag, Serhat
Ozturk, Savas
Gursu, Meltem
Gurdal, Ahmet
Basinoglu, Filiz
Yigit, Servet
Aydin, Zeki
Uzun, Sami
Sumnu, Abdullah
Oflaz, Huseyin
Kazancioglu, Rumeyza
author_facet Karadag, Serhat
Ozturk, Savas
Gursu, Meltem
Gurdal, Ahmet
Basinoglu, Filiz
Yigit, Servet
Aydin, Zeki
Uzun, Sami
Sumnu, Abdullah
Oflaz, Huseyin
Kazancioglu, Rumeyza
author_sort Karadag, Serhat
collection PubMed
description BACKGROUND: Many markers have been proposed for CVD risk assessment in dialysis population. Apelin is a peptide that has roles in cardiovascular functions and volume regulation namely vasodilation, decreased blood pressure (BP), positive inotropic effect and inhibition of antidiuretic hormone release. The aim of this study was to examine relationship of apelin levels with echocardiographic findings and laboratory parameters related with cardiovascular function and bone mineral metabolism among peritoneal dialysis (PD) patients. METHODS: This is a cross-sectional study in which chronic PD patients aged between 18 and 80 without active cardiac, infectious or malignant diseases and hypervolemia have been included. Apelin-36 levels and echocardiographic findings were recorded as well as clinical and laboratory data. RESULTS: Of the 53 patients, the mean age and female/male ratio was 52.8 ± 15.3 years and 30/23, respectively. Mean apelin level was 1.45 ± 0.37 ng/ml. Gender, drugs (renin-angiotensin-aldosteron inhibitors, statins), presence of left ventricular hypertrophy, diabetes mellitus, hypertension, hyperlipidemia and significant residual renal function did not affect apelin-36 levels. Apelin-36 was correlated negatively with age and left atrium diameter; and positively with diastolic BP, ejection fraction (EF), total cholesterol, LDL-cholesterol, HDL-cholesterol, parathyroid hormone and alkaline phosphatase (ALP) levels. Diastolic BP, LDL-cholesterol, ALP and EF were found to be the independent determinants of apelin-36 levels with linear regression analysis. CONCLUSIONS: Apelinergic system has important roles in volume regulation, cardiovascular functions, lipid metabolism and bone mineral disorders in PD patients. Prospective studies with large population are required.
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spelling pubmed-39308242014-02-22 The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker? Karadag, Serhat Ozturk, Savas Gursu, Meltem Gurdal, Ahmet Basinoglu, Filiz Yigit, Servet Aydin, Zeki Uzun, Sami Sumnu, Abdullah Oflaz, Huseyin Kazancioglu, Rumeyza BMC Nephrol Research Article BACKGROUND: Many markers have been proposed for CVD risk assessment in dialysis population. Apelin is a peptide that has roles in cardiovascular functions and volume regulation namely vasodilation, decreased blood pressure (BP), positive inotropic effect and inhibition of antidiuretic hormone release. The aim of this study was to examine relationship of apelin levels with echocardiographic findings and laboratory parameters related with cardiovascular function and bone mineral metabolism among peritoneal dialysis (PD) patients. METHODS: This is a cross-sectional study in which chronic PD patients aged between 18 and 80 without active cardiac, infectious or malignant diseases and hypervolemia have been included. Apelin-36 levels and echocardiographic findings were recorded as well as clinical and laboratory data. RESULTS: Of the 53 patients, the mean age and female/male ratio was 52.8 ± 15.3 years and 30/23, respectively. Mean apelin level was 1.45 ± 0.37 ng/ml. Gender, drugs (renin-angiotensin-aldosteron inhibitors, statins), presence of left ventricular hypertrophy, diabetes mellitus, hypertension, hyperlipidemia and significant residual renal function did not affect apelin-36 levels. Apelin-36 was correlated negatively with age and left atrium diameter; and positively with diastolic BP, ejection fraction (EF), total cholesterol, LDL-cholesterol, HDL-cholesterol, parathyroid hormone and alkaline phosphatase (ALP) levels. Diastolic BP, LDL-cholesterol, ALP and EF were found to be the independent determinants of apelin-36 levels with linear regression analysis. CONCLUSIONS: Apelinergic system has important roles in volume regulation, cardiovascular functions, lipid metabolism and bone mineral disorders in PD patients. Prospective studies with large population are required. BioMed Central 2014-01-16 /pmc/articles/PMC3930824/ /pubmed/24433492 http://dx.doi.org/10.1186/1471-2369-15-18 Text en Copyright © 2014 Karadag et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Karadag, Serhat
Ozturk, Savas
Gursu, Meltem
Gurdal, Ahmet
Basinoglu, Filiz
Yigit, Servet
Aydin, Zeki
Uzun, Sami
Sumnu, Abdullah
Oflaz, Huseyin
Kazancioglu, Rumeyza
The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
title The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
title_full The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
title_fullStr The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
title_full_unstemmed The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
title_short The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
title_sort relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930824/
https://www.ncbi.nlm.nih.gov/pubmed/24433492
http://dx.doi.org/10.1186/1471-2369-15-18
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