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Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis
INTRODUCTION: Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) contains high amounts of GLA. Therefore, this study investigated whether EPO supplementatio...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930832/ https://www.ncbi.nlm.nih.gov/pubmed/24435467 http://dx.doi.org/10.1007/s12325-014-0093-0 |
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author | Simon, Dagmar Eng, Peter A. Borelli, Siegfried Kägi, Roland Zimmermann, Christian Zahner, Catherine Drewe, Jürgen Hess, Lorenzo Ferrari, Giovanni Lautenschlager, Stephan Wüthrich, Brunello Schmid-Grendelmeier, Peter |
author_facet | Simon, Dagmar Eng, Peter A. Borelli, Siegfried Kägi, Roland Zimmermann, Christian Zahner, Catherine Drewe, Jürgen Hess, Lorenzo Ferrari, Giovanni Lautenschlager, Stephan Wüthrich, Brunello Schmid-Grendelmeier, Peter |
author_sort | Simon, Dagmar |
collection | PubMed |
description | INTRODUCTION: Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) contains high amounts of GLA. Therefore, this study investigated whether EPO supplementation results in an increase in plasma GLA and its metabolite dihomo-gamma-linolenic acid (DGLA) correlating with clinical improvement of AD, assessed by the SCORing Atopic Dermatitis (SCORAD) index. METHODS: The open study included 21 patients with AD. EPO (4–6 g) was administered daily for 12 weeks. Before treatment, and 4 and 12 weeks after initiation of EPO supplementation, objective SCORAD was assessed and plasma concentrations of GLA and DGLA were determined by gas chromatography. RESULTS: A significant increase in plasma GLA and DGLA levels and a decrease in the objective SCORAD were observed 4 and 12 weeks after initiation of EPO treatment. In the per-protocol population (n = 14), a significant inverse correlation between the changes in plasma GLA levels and SCORAD was found (P = 0.008). CONCLUSION: The clinical disease activity under EPO treatment correlates with the individual increase in plasma GLA levels. Thus, the results of this pilot study indicate that an increase in plasma GLA might be used as predictive parameter for responsiveness of AD to EPO therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12325-014-0093-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3930832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-39308322014-02-28 Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis Simon, Dagmar Eng, Peter A. Borelli, Siegfried Kägi, Roland Zimmermann, Christian Zahner, Catherine Drewe, Jürgen Hess, Lorenzo Ferrari, Giovanni Lautenschlager, Stephan Wüthrich, Brunello Schmid-Grendelmeier, Peter Adv Ther Original Research INTRODUCTION: Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) contains high amounts of GLA. Therefore, this study investigated whether EPO supplementation results in an increase in plasma GLA and its metabolite dihomo-gamma-linolenic acid (DGLA) correlating with clinical improvement of AD, assessed by the SCORing Atopic Dermatitis (SCORAD) index. METHODS: The open study included 21 patients with AD. EPO (4–6 g) was administered daily for 12 weeks. Before treatment, and 4 and 12 weeks after initiation of EPO supplementation, objective SCORAD was assessed and plasma concentrations of GLA and DGLA were determined by gas chromatography. RESULTS: A significant increase in plasma GLA and DGLA levels and a decrease in the objective SCORAD were observed 4 and 12 weeks after initiation of EPO treatment. In the per-protocol population (n = 14), a significant inverse correlation between the changes in plasma GLA levels and SCORAD was found (P = 0.008). CONCLUSION: The clinical disease activity under EPO treatment correlates with the individual increase in plasma GLA levels. Thus, the results of this pilot study indicate that an increase in plasma GLA might be used as predictive parameter for responsiveness of AD to EPO therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12325-014-0093-0) contains supplementary material, which is available to authorized users. Springer Healthcare 2014-01-17 2014 /pmc/articles/PMC3930832/ /pubmed/24435467 http://dx.doi.org/10.1007/s12325-014-0093-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Research Simon, Dagmar Eng, Peter A. Borelli, Siegfried Kägi, Roland Zimmermann, Christian Zahner, Catherine Drewe, Jürgen Hess, Lorenzo Ferrari, Giovanni Lautenschlager, Stephan Wüthrich, Brunello Schmid-Grendelmeier, Peter Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis |
title | Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis |
title_full | Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis |
title_fullStr | Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis |
title_full_unstemmed | Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis |
title_short | Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis |
title_sort | gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930832/ https://www.ncbi.nlm.nih.gov/pubmed/24435467 http://dx.doi.org/10.1007/s12325-014-0093-0 |
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