Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

Most hereditary periodic fever syndromes are mediated by deregulated IL-1β secretion. The generation of mature IL-1β requires two signals: one that induces synthesis of inflammasome components and substrates and a second that activates inflammasomes. The mechanisms that mediate autoinflammation in m...

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Detalles Bibliográficos
Autores principales: van der Burgh, Robert, Nijhuis, Lotte, Pervolaraki, Kalliopi, Compeer, Ewoud B., Jongeneel, Lieneke H., van Gijn, Marielle, Coffer, Paul J., Murphy, Michael P., Mastroberardino, Pier G., Frenkel, Joost, Boes, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931060/
https://www.ncbi.nlm.nih.gov/pubmed/24356959
http://dx.doi.org/10.1074/jbc.M113.536920

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