SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, show modification downstream of this domain, and dem...

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Detalles Bibliográficos
Autores principales: O’Rourke, Jacqueline Gire, Gareau, Jaclyn R., Ochaba, Joseph, Song, Wan, Raskó, Tamás, Reverter, David, Lee, John, Monteys, Alex Mas, Pallos, Judit, Mee, Lisa, Vashishtha, Malini, Apostol, Barbara L., Nicholson, Thomas Peter, Illes, Katalin, Zhu, Ya-Zhen, Dasso, Mary, Bates, Gillian P., Difiglia, Marian, Davidson, Beverly, Wanker, Erich E., Marsh, J. Lawrence, Lima, Christopher D., Steffan, Joan S., Thompson, Leslie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931302/
https://www.ncbi.nlm.nih.gov/pubmed/23871671
http://dx.doi.org/10.1016/j.celrep.2013.06.034

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