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Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality

BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific Cdk5 conditional knockout (cKO) mice displayed an early lethality associat...

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Detalles Bibliográficos
Autores principales:	Utreras, Elias, Hamada, Ryusuke, Prochazkova, Michaela, Terse, Anita, Takahashi, Satoru, Ohshima, Toshio, Kulkarni, Ashok B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931315/ https://www.ncbi.nlm.nih.gov/pubmed/24495352 http://dx.doi.org/10.1186/1742-2094-11-28

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