Targeted Disruption of G(0)/G(1) Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet–Induced Liver Steatosis

Recent biochemical and cell-based studies identified G(0)/G(1) switch gene 2 (G0S2) as an inhibitor of adipose triglyceride lipase (ATGL), a key mediator of intracellular triacylglycerol (TG) mobilization. Here, we show that upon fasting, G0S2 protein expression exhibits an increase in liver and a d...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaodong, Xie, Xitao, Heckmann, Bradlee L., Saarinen, Alicia M., Czyzyk, Traci A., Liu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931401/
https://www.ncbi.nlm.nih.gov/pubmed/24194501
http://dx.doi.org/10.2337/db13-1422

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