Compensating for the Absence of Selenocysteine in High-Molecular Weight Thioredoxin Reductases: The Electrophilic Activation Hypothesis

[Image: see text] Mammalian thioredoxin reductase (TR) is a pyridine disulfide oxidoreductase that uses the rare amino acid selenocysteine (Sec) in place of the more commonly used amino acid cysteine (Cys). Selenium is a Janus-faced element because it is both highly nucleophilic and highly electroph...

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Detalles Bibliográficos
Autores principales: Lothrop, Adam P., Snider, Gregg W., Flemer, Stevenson, Ruggles, Erik L., Davidson, Ronald S., Lamb, Audrey L., Hondal, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931472/
https://www.ncbi.nlm.nih.gov/pubmed/24490974
http://dx.doi.org/10.1021/bi4007258

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