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Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes

The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)–C(16)-iron oxide (PHEA-C(16)-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C(16)-iron oxide nanoparticles were synthesized...

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Autores principales: Ha, Dae Chul, Lee, Ha Young, Son, Yeo Won, Yuk, Soon Hong, Choi, Youn Woong, Kwak, Byung Kook, Shin, Byung Cheol, Cho, Cheong-Weon, Cho, Sun Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931668/
https://www.ncbi.nlm.nih.gov/pubmed/24438671
http://dx.doi.org/10.1186/1556-276X-9-38
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author Ha, Dae Chul
Lee, Ha Young
Son, Yeo Won
Yuk, Soon Hong
Choi, Youn Woong
Kwak, Byung Kook
Shin, Byung Cheol
Cho, Cheong-Weon
Cho, Sun Hang
author_facet Ha, Dae Chul
Lee, Ha Young
Son, Yeo Won
Yuk, Soon Hong
Choi, Youn Woong
Kwak, Byung Kook
Shin, Byung Cheol
Cho, Cheong-Weon
Cho, Sun Hang
author_sort Ha, Dae Chul
collection PubMed
description The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)–C(16)-iron oxide (PHEA-C(16)-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C(16)-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C(16)-iron oxide nanoparticles was about 5 to 7 nm, and the overall size of the nanoparticles was around 20, 60, and 150 nm in aqueous solution. The size of the nanoparticles was controlled by the amount of C(16). The 3.0-T MRI signal intensity of a rabbit lymph node was effectively reduced after intravenous administration of PHEA-C(16)-iron oxide with the size of 20 nm. The in vitro and in vivo toxicity tests revealed the high biocompatibility of PHEA-C(16)-iron oxide nanoparticles. Therefore, PHEA-C(16)-iron oxide nanoparticles with 20-nm size can be potentially useful as T2-weighted MR imaging contrast agents for the detection of lymph nodes.
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spelling pubmed-39316682014-02-24 Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes Ha, Dae Chul Lee, Ha Young Son, Yeo Won Yuk, Soon Hong Choi, Youn Woong Kwak, Byung Kook Shin, Byung Cheol Cho, Cheong-Weon Cho, Sun Hang Nanoscale Res Lett Nano Express The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)–C(16)-iron oxide (PHEA-C(16)-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C(16)-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C(16)-iron oxide nanoparticles was about 5 to 7 nm, and the overall size of the nanoparticles was around 20, 60, and 150 nm in aqueous solution. The size of the nanoparticles was controlled by the amount of C(16). The 3.0-T MRI signal intensity of a rabbit lymph node was effectively reduced after intravenous administration of PHEA-C(16)-iron oxide with the size of 20 nm. The in vitro and in vivo toxicity tests revealed the high biocompatibility of PHEA-C(16)-iron oxide nanoparticles. Therefore, PHEA-C(16)-iron oxide nanoparticles with 20-nm size can be potentially useful as T2-weighted MR imaging contrast agents for the detection of lymph nodes. Springer 2014-01-18 /pmc/articles/PMC3931668/ /pubmed/24438671 http://dx.doi.org/10.1186/1556-276X-9-38 Text en Copyright © 2014 Ha et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nano Express
Ha, Dae Chul
Lee, Ha Young
Son, Yeo Won
Yuk, Soon Hong
Choi, Youn Woong
Kwak, Byung Kook
Shin, Byung Cheol
Cho, Cheong-Weon
Cho, Sun Hang
Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
title Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
title_full Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
title_fullStr Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
title_full_unstemmed Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
title_short Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
title_sort preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for mr imaging of lymph nodes
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931668/
https://www.ncbi.nlm.nih.gov/pubmed/24438671
http://dx.doi.org/10.1186/1556-276X-9-38
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