Cargando…
Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes
The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)–C(16)-iron oxide (PHEA-C(16)-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C(16)-iron oxide nanoparticles were synthesized...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931668/ https://www.ncbi.nlm.nih.gov/pubmed/24438671 http://dx.doi.org/10.1186/1556-276X-9-38 |
_version_ | 1782304692141817856 |
---|---|
author | Ha, Dae Chul Lee, Ha Young Son, Yeo Won Yuk, Soon Hong Choi, Youn Woong Kwak, Byung Kook Shin, Byung Cheol Cho, Cheong-Weon Cho, Sun Hang |
author_facet | Ha, Dae Chul Lee, Ha Young Son, Yeo Won Yuk, Soon Hong Choi, Youn Woong Kwak, Byung Kook Shin, Byung Cheol Cho, Cheong-Weon Cho, Sun Hang |
author_sort | Ha, Dae Chul |
collection | PubMed |
description | The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)–C(16)-iron oxide (PHEA-C(16)-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C(16)-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C(16)-iron oxide nanoparticles was about 5 to 7 nm, and the overall size of the nanoparticles was around 20, 60, and 150 nm in aqueous solution. The size of the nanoparticles was controlled by the amount of C(16). The 3.0-T MRI signal intensity of a rabbit lymph node was effectively reduced after intravenous administration of PHEA-C(16)-iron oxide with the size of 20 nm. The in vitro and in vivo toxicity tests revealed the high biocompatibility of PHEA-C(16)-iron oxide nanoparticles. Therefore, PHEA-C(16)-iron oxide nanoparticles with 20-nm size can be potentially useful as T2-weighted MR imaging contrast agents for the detection of lymph nodes. |
format | Online Article Text |
id | pubmed-3931668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-39316682014-02-24 Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes Ha, Dae Chul Lee, Ha Young Son, Yeo Won Yuk, Soon Hong Choi, Youn Woong Kwak, Byung Kook Shin, Byung Cheol Cho, Cheong-Weon Cho, Sun Hang Nanoscale Res Lett Nano Express The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)–C(16)-iron oxide (PHEA-C(16)-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C(16)-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C(16)-iron oxide nanoparticles was about 5 to 7 nm, and the overall size of the nanoparticles was around 20, 60, and 150 nm in aqueous solution. The size of the nanoparticles was controlled by the amount of C(16). The 3.0-T MRI signal intensity of a rabbit lymph node was effectively reduced after intravenous administration of PHEA-C(16)-iron oxide with the size of 20 nm. The in vitro and in vivo toxicity tests revealed the high biocompatibility of PHEA-C(16)-iron oxide nanoparticles. Therefore, PHEA-C(16)-iron oxide nanoparticles with 20-nm size can be potentially useful as T2-weighted MR imaging contrast agents for the detection of lymph nodes. Springer 2014-01-18 /pmc/articles/PMC3931668/ /pubmed/24438671 http://dx.doi.org/10.1186/1556-276X-9-38 Text en Copyright © 2014 Ha et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Nano Express Ha, Dae Chul Lee, Ha Young Son, Yeo Won Yuk, Soon Hong Choi, Youn Woong Kwak, Byung Kook Shin, Byung Cheol Cho, Cheong-Weon Cho, Sun Hang Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes |
title | Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes |
title_full | Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes |
title_fullStr | Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes |
title_full_unstemmed | Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes |
title_short | Preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for MR imaging of lymph nodes |
title_sort | preparation and evaluation of poly(2-hydroxyethyl aspartamide)-hexadecylamine-iron oxide for mr imaging of lymph nodes |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931668/ https://www.ncbi.nlm.nih.gov/pubmed/24438671 http://dx.doi.org/10.1186/1556-276X-9-38 |
work_keys_str_mv | AT hadaechul preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT leehayoung preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT sonyeowon preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT yuksoonhong preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT choiyounwoong preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT kwakbyungkook preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT shinbyungcheol preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT chocheongweon preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes AT chosunhang preparationandevaluationofpoly2hydroxyethylaspartamidehexadecylamineironoxideformrimagingoflymphnodes |