HTLV-1 Tax Oncoprotein Inhibits the Estrogen-Induced-ER α-Mediated BRCA1 Expression by Interaction with CBP/p300 Cofactors

BRCA1 is a multifunctional tumor suppressor, whose expression is activated by the estrogen (E2)-liganded ERα receptor and regulated by certain recruited transcriptional co-activators. Interference with BRCA1 expression and/or functions leads to high risk of breast or/and ovarian cancer. Another mult...

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Detalles Bibliográficos
Autores principales: Shukrun, Meital, Jabareen, Azhar, Abou-Kandil, Ammar, Chamias, Rachel, Aboud, Mordechai, Huleihel, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931753/
https://www.ncbi.nlm.nih.gov/pubmed/24586743
http://dx.doi.org/10.1371/journal.pone.0089390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931753/
https://www.ncbi.nlm.nih.gov/pubmed/24586743
http://dx.doi.org/10.1371/journal.pone.0089390

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