TALEN-Mediated Modification of the Bovine Genome for Large-Scale Production of Human Serum Albumin

As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimulated homology-directed repair (HDR). Pedigreed bo...

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Detalles Bibliográficos
Autores principales: Moghaddassi, Shaida, Eyestone, Will, Bishop, Colin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931800/
https://www.ncbi.nlm.nih.gov/pubmed/24586924
http://dx.doi.org/10.1371/journal.pone.0089631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931800/
https://www.ncbi.nlm.nih.gov/pubmed/24586924
http://dx.doi.org/10.1371/journal.pone.0089631

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