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TALEN-Mediated Modification of the Bovine Genome for Large-Scale Production of Human Serum Albumin
As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimulated homology-directed repair (HDR). Pedigreed bo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931800/ https://www.ncbi.nlm.nih.gov/pubmed/24586924 http://dx.doi.org/10.1371/journal.pone.0089631 |