Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

PURPOSE: A versatile methodology is demonstrated for improving dissolution kinetics, gastrointestinal (GI) absorption, and bioavailability of protein kinase inhibitors (PKIs). METHODS: The approach is based on nanoparticle precipitation by sub- or supercritical CO(2) together with a matrix-forming p...

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Detalles Bibliográficos
Autores principales: Jesson, Gérald, Brisander, Magnus, Andersson, Per, Demirbüker, Mustafa, Derand, Helene, Lennernäs, Hans, Malmsten, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931930/
https://www.ncbi.nlm.nih.gov/pubmed/23990314
http://dx.doi.org/10.1007/s11095-013-1191-4

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