Extraction of tamoxifen and its metabolites from formalin-fixed, paraffin-embedded tissues: an innovative quantitation method using liquid chromatography and tandem mass spectrometry

PURPOSE: Tamoxifen is a key therapeutic option for breast cancer treatment. Understanding its complex metabolism and pharmacokinetics is important for dose optimization. We examined the possibility of utilizing archival formalin-fixed paraffin-embedded (FFPE) tissue as an alternative sample source f...

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Detalles Bibliográficos
Autores principales: Ng, Ella S. M., Kangarloo, S. Bill, Konno, Mie, Paterson, Alexander, Magliocco, Anthony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931943/
https://www.ncbi.nlm.nih.gov/pubmed/24414550
http://dx.doi.org/10.1007/s00280-013-2346-z

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