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The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer

Introduction. Our objective was to identify mutations in the K-RAS gene in cases of pulmonary metastases from colorectal cancer (CRC) and determine whether their presence was a prognostic factor for survival. Methods. We included all patients with pulmonary metastases from CRC operated on between 19...

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Autores principales: Zabaleta, Jon, Aguinagalde, Borja, Izquierdo, José M., Bazterargui, Nerea, Laguna, Stephany M., Martin-Arruti, Maialen, Lobo, Carmen, Emparanza, José I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932217/
https://www.ncbi.nlm.nih.gov/pubmed/24649376
http://dx.doi.org/10.1155/2014/157586
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author Zabaleta, Jon
Aguinagalde, Borja
Izquierdo, José M.
Bazterargui, Nerea
Laguna, Stephany M.
Martin-Arruti, Maialen
Lobo, Carmen
Emparanza, José I.
author_facet Zabaleta, Jon
Aguinagalde, Borja
Izquierdo, José M.
Bazterargui, Nerea
Laguna, Stephany M.
Martin-Arruti, Maialen
Lobo, Carmen
Emparanza, José I.
author_sort Zabaleta, Jon
collection PubMed
description Introduction. Our objective was to identify mutations in the K-RAS gene in cases of pulmonary metastases from colorectal cancer (CRC) and determine whether their presence was a prognostic factor for survival. Methods. We included all patients with pulmonary metastases from CRC operated on between 1998 and 2010. K-RAS mutations were investigated by direct sequencing of DNA. Differences in survival were explored with the Kaplan-Meier method log-rank tests and multivariate Cox regression analysis. Results. 110 surgical interventions were performed on 90 patients. Factors significantly associated with survival were disease-free interval (P = 0.002), age (P = 0.007), number of metastases (P = 0.001), lymph node involvement (P = 0.007), size of the metastases (P = 0.013), and previous liver metastasis (P = 0.003). Searching in 79 patients, K-RAS mutations were found in 30 cases. We did not find statistically significant differences in survival (P = 0.913) comparing native and mutated K-RAS. We found a higher rate of lung recurrence (P = 0.040) and shorter time to recurrence (P = 0.015) in patients with K-RAS mutations. Gly12Asp mutation was associated with higher recurrence (P = 0.022) and lower survival (P = 0.389). Conclusions. The presence of K-RAS mutations in pulmonary metastases does not affect overall survival but is associated with higher rates of pulmonary recurrence.
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spelling pubmed-39322172014-03-19 The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer Zabaleta, Jon Aguinagalde, Borja Izquierdo, José M. Bazterargui, Nerea Laguna, Stephany M. Martin-Arruti, Maialen Lobo, Carmen Emparanza, José I. ISRN Surg Clinical Study Introduction. Our objective was to identify mutations in the K-RAS gene in cases of pulmonary metastases from colorectal cancer (CRC) and determine whether their presence was a prognostic factor for survival. Methods. We included all patients with pulmonary metastases from CRC operated on between 1998 and 2010. K-RAS mutations were investigated by direct sequencing of DNA. Differences in survival were explored with the Kaplan-Meier method log-rank tests and multivariate Cox regression analysis. Results. 110 surgical interventions were performed on 90 patients. Factors significantly associated with survival were disease-free interval (P = 0.002), age (P = 0.007), number of metastases (P = 0.001), lymph node involvement (P = 0.007), size of the metastases (P = 0.013), and previous liver metastasis (P = 0.003). Searching in 79 patients, K-RAS mutations were found in 30 cases. We did not find statistically significant differences in survival (P = 0.913) comparing native and mutated K-RAS. We found a higher rate of lung recurrence (P = 0.040) and shorter time to recurrence (P = 0.015) in patients with K-RAS mutations. Gly12Asp mutation was associated with higher recurrence (P = 0.022) and lower survival (P = 0.389). Conclusions. The presence of K-RAS mutations in pulmonary metastases does not affect overall survival but is associated with higher rates of pulmonary recurrence. Hindawi Publishing Corporation 2014-02-04 /pmc/articles/PMC3932217/ /pubmed/24649376 http://dx.doi.org/10.1155/2014/157586 Text en Copyright © 2014 Jon Zabaleta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Zabaleta, Jon
Aguinagalde, Borja
Izquierdo, José M.
Bazterargui, Nerea
Laguna, Stephany M.
Martin-Arruti, Maialen
Lobo, Carmen
Emparanza, José I.
The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer
title The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer
title_full The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer
title_fullStr The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer
title_full_unstemmed The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer
title_short The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer
title_sort presence of mutations in the k-ras gene does not affect survival after resection of pulmonary metastases from colorectal cancer
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932217/
https://www.ncbi.nlm.nih.gov/pubmed/24649376
http://dx.doi.org/10.1155/2014/157586
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