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2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks

Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H(2)O(...

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Detalles Bibliográficos
Autores principales: Park, Jinah, Lee, Sunmi, Lee, Sanghyuk, Kang, Sang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932224/
https://www.ncbi.nlm.nih.gov/pubmed/24672551
http://dx.doi.org/10.1155/2014/715867
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author Park, Jinah
Lee, Sunmi
Lee, Sanghyuk
Kang, Sang Won
author_facet Park, Jinah
Lee, Sunmi
Lee, Sanghyuk
Kang, Sang Won
author_sort Park, Jinah
collection PubMed
description Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H(2)O(2). In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase. These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.
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spelling pubmed-39322242014-03-26 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks Park, Jinah Lee, Sunmi Lee, Sanghyuk Kang, Sang Won Int J Cell Biol Review Article Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H(2)O(2). In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase. These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling. Hindawi Publishing Corporation 2014 2014-02-04 /pmc/articles/PMC3932224/ /pubmed/24672551 http://dx.doi.org/10.1155/2014/715867 Text en Copyright © 2014 Jinah Park et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Park, Jinah
Lee, Sunmi
Lee, Sanghyuk
Kang, Sang Won
2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
title 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
title_full 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
title_fullStr 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
title_full_unstemmed 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
title_short 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
title_sort 2-cys peroxiredoxins: emerging hubs determining redox dependency of mammalian signaling networks
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932224/
https://www.ncbi.nlm.nih.gov/pubmed/24672551
http://dx.doi.org/10.1155/2014/715867
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