The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway

BACKGROUND: Although tumor hypoxia poses challenges against conventional cancer treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the effect of the hypoxia-activated synthetic quinoxaline di-N-oxide DCQ against breast cancer metastasis and identified the unde...

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Detalles Bibliográficos
Autores principales: Ghattass, Khaled, El-Sitt, Sally, Zibara, Kazem, Rayes, Saide, Haddadin, Makhluf J, El-Sabban, Marwan, Gali-Muhtasib, Hala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932516/
https://www.ncbi.nlm.nih.gov/pubmed/24461075
http://dx.doi.org/10.1186/1476-4598-13-12

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