Cargando…

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Mitochondrial antiviral signaling (MAVS) protein is required for innate immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like aggregates to activate antiviral signaling cascades, but the underlying structural mechanism is unknown. Here we report cryo-electron microscopi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Hui, He, Xiaojing, Zheng, Hui, Huang, Lily J, Hou, Fajian, Yu, Zhiheng, de la Cruz, Michael Jason, Borkowski, Brian, Zhang, Xuewu, Chen, Zhijian J, Jiang, Qiu-Xing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932521/ https://www.ncbi.nlm.nih.gov/pubmed/24569476 http://dx.doi.org/10.7554/eLife.01489

Ejemplares similares

Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2015)

WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response
por: Li, Jiaxin, et al.
Publicado: (2023)

Author Correction: WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response
por: Li, Jiaxin, et al.
Publicado: (2023)

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
por: Qi, Nan, et al.
Publicado: (2017)

An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response
por: Shi, Yuheng, et al.
Publicado: (2015)

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments
por: Tang, Shaogeng, et al.
Publicado: (2015)

The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
por: Zhang, Rui, et al.
Publicado: (2022)

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
por: Shi, Yuheng, et al.
Publicado: (2017)

Structural basis of dynamic P5CS filaments
por: Zhong, Jiale, et al.
Publicado: (2022)

Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor
por: Lane-Serff, Harriet, et al.
Publicado: (2014)

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments
por: Barski, Michal, et al.
Publicado: (2017)

Side-binding proteins modulate actin filament dynamics
por: Crevenna, Alvaro H, et al.
Publicado: (2015)

Myosin motors fragment and compact membrane-bound actin filaments
por: Vogel, Sven K, et al.
Publicado: (2013)

Physical basis of large microtubule aster growth
por: Ishihara, Keisuke, et al.
Publicado: (2016)

Model for a novel membrane envelope in a filamentous hyperthermophilic virus
por: Kasson, Peter, et al.
Publicado: (2017)

Three-stranded antiviral attack
por: Patel, Jenish R, et al.
Publicado: (2014)

Crenactin forms actin-like double helical filaments regulated by arcadin-2
por: Izoré, Thierry, et al.
Publicado: (2016)

Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle
por: Zhang, Xuemeng, et al.
Publicado: (2017)

Structural basis of interprotein electron transfer in bacterial sulfite oxidation
por: McGrath, Aaron P, et al.
Publicado: (2015)

SARS-CoV-2 infection and the antiviral innate immune response
por: Yang, Hui, et al.
Publicado: (2020)

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks
por: Christensen, Jenna R, et al.
Publicado: (2017)

Structural basis for germline antibody recognition of HIV-1 immunogens
por: Scharf, Louise, et al.
Publicado: (2016)

The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome
por: McCann, Kathleen L, et al.
Publicado: (2016)

Structural basis for DNA 5´-end resection by RecJ
por: Cheng, Kaiying, et al.
Publicado: (2016)

Biophysical basis for convergent evolution of two veil-forming microbes
por: Petroff, Alexander P., et al.
Publicado: (2015)

Molecular basis of sidekick-mediated cell-cell adhesion and specificity
por: Goodman, Kerry M, et al.
Publicado: (2016)

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers
por: Scholey, Jessica E, et al.
Publicado: (2014)

Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis
por: Paul, Blessy, et al.
Publicado: (2017)

Filamentation modulates allosteric regulation of PRPS
por: Hu, Huan-Huan, et al.
Publicado: (2022)

A Dynamic molecular basis for malfunction in disease mutants of p97/VCP
por: Schuetz, Anne K, et al.
Publicado: (2016)

Structural basis for subtype-specific inhibition of the P2X7 receptor
por: Karasawa, Akira, et al.
Publicado: (2016)

The near-atomic cryoEM structure of a flexible filamentous plant virus shows homology of its coat protein with nucleoproteins of animal viruses
por: Agirrezabala, Xabier, et al.
Publicado: (2015)

The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex
por: Stratmann, Sarah A, et al.
Publicado: (2015)

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1
por: Butryn, Agata, et al.
Publicado: (2015)

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones
por: Wilkinson, Martin, et al.
Publicado: (2016)

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
por: Paulino, Cristina, et al.
Publicado: (2017)

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex
por: Shang, Guijun, et al.
Publicado: (2017)

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation
por: Shang, Zhiguo, et al.
Publicado: (2014)

Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor
por: Maqbool, A, et al.
Publicado: (2015)

Anti-prion activity of an RNA aptamer and its structural basis
por: Mashima, Tsukasa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_rdengkhsjb6r6bvclpe87ct9ns