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Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
OBJECTIVE: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932596/ https://www.ncbi.nlm.nih.gov/pubmed/24604958 http://dx.doi.org/10.4103/0971-5851.125245 |
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author | Mukhopadhyay, Ashis Gangopadhyay, Sudeshna Dasgupta, Swati Paul, Samrat Mukhopadhyay, Soma Ray, Ujjal Kanti |
author_facet | Mukhopadhyay, Ashis Gangopadhyay, Sudeshna Dasgupta, Swati Paul, Samrat Mukhopadhyay, Soma Ray, Ujjal Kanti |
author_sort | Mukhopadhyay, Ashis |
collection | PubMed |
description | OBJECTIVE: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. MATERIALS AND METHODS: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. RESULTS: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. CONCLUSIONS: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome. |
format | Online Article Text |
id | pubmed-3932596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39325962014-03-06 Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India Mukhopadhyay, Ashis Gangopadhyay, Sudeshna Dasgupta, Swati Paul, Samrat Mukhopadhyay, Soma Ray, Ujjal Kanti Indian J Med Paediatr Oncol Original Article OBJECTIVE: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. MATERIALS AND METHODS: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. RESULTS: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. CONCLUSIONS: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3932596/ /pubmed/24604958 http://dx.doi.org/10.4103/0971-5851.125245 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mukhopadhyay, Ashis Gangopadhyay, Sudeshna Dasgupta, Swati Paul, Samrat Mukhopadhyay, Soma Ray, Ujjal Kanti Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
title | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
title_full | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
title_fullStr | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
title_full_unstemmed | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
title_short | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
title_sort | surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: an experience from eastern india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932596/ https://www.ncbi.nlm.nih.gov/pubmed/24604958 http://dx.doi.org/10.4103/0971-5851.125245 |
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