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Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India

OBJECTIVE: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface...

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Autores principales: Mukhopadhyay, Ashis, Gangopadhyay, Sudeshna, Dasgupta, Swati, Paul, Samrat, Mukhopadhyay, Soma, Ray, Ujjal Kanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932596/
https://www.ncbi.nlm.nih.gov/pubmed/24604958
http://dx.doi.org/10.4103/0971-5851.125245
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author Mukhopadhyay, Ashis
Gangopadhyay, Sudeshna
Dasgupta, Swati
Paul, Samrat
Mukhopadhyay, Soma
Ray, Ujjal Kanti
author_facet Mukhopadhyay, Ashis
Gangopadhyay, Sudeshna
Dasgupta, Swati
Paul, Samrat
Mukhopadhyay, Soma
Ray, Ujjal Kanti
author_sort Mukhopadhyay, Ashis
collection PubMed
description OBJECTIVE: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. MATERIALS AND METHODS: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. RESULTS: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. CONCLUSIONS: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome.
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spelling pubmed-39325962014-03-06 Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India Mukhopadhyay, Ashis Gangopadhyay, Sudeshna Dasgupta, Swati Paul, Samrat Mukhopadhyay, Soma Ray, Ujjal Kanti Indian J Med Paediatr Oncol Original Article OBJECTIVE: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. MATERIALS AND METHODS: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. RESULTS: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. CONCLUSIONS: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3932596/ /pubmed/24604958 http://dx.doi.org/10.4103/0971-5851.125245 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mukhopadhyay, Ashis
Gangopadhyay, Sudeshna
Dasgupta, Swati
Paul, Samrat
Mukhopadhyay, Soma
Ray, Ujjal Kanti
Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
title Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
title_full Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
title_fullStr Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
title_full_unstemmed Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
title_short Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
title_sort surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: an experience from eastern india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932596/
https://www.ncbi.nlm.nih.gov/pubmed/24604958
http://dx.doi.org/10.4103/0971-5851.125245
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