Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics

The use of all trans-retinoic acid (ATRA) and combination chemotherapy has made acute promyelocytic leukemia (APL) a potentially curable leukemia. Late sequelae of the treatment of APL have therefore become an important consideration in the overall treatment strategy. We report a patient with APL wh...

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Autores principales: Sahoo, Ranjit Kumar, Kumar, Lalit, Kumar, Rajive, Sharma, Atul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932606/
https://www.ncbi.nlm.nih.gov/pubmed/24604968
http://dx.doi.org/10.4103/0971-5851.125261
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author Sahoo, Ranjit Kumar
Kumar, Lalit
Kumar, Rajive
Sharma, Atul
author_facet Sahoo, Ranjit Kumar
Kumar, Lalit
Kumar, Rajive
Sharma, Atul
author_sort Sahoo, Ranjit Kumar
collection PubMed
description The use of all trans-retinoic acid (ATRA) and combination chemotherapy has made acute promyelocytic leukemia (APL) a potentially curable leukemia. Late sequelae of the treatment of APL have therefore become an important consideration in the overall treatment strategy. We report a patient with APL who achieved complete clinical and molecular remission after treatment with daunorubicin and ATRA. Three years later, she developed acute myeloid leukemia (AML), M2 subtype without any evidence of relapse of the APL clone. Karyotypic analysis showed a normal female karyotype.
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spelling pubmed-39326062014-03-06 Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics Sahoo, Ranjit Kumar Kumar, Lalit Kumar, Rajive Sharma, Atul Indian J Med Paediatr Oncol Case Report The use of all trans-retinoic acid (ATRA) and combination chemotherapy has made acute promyelocytic leukemia (APL) a potentially curable leukemia. Late sequelae of the treatment of APL have therefore become an important consideration in the overall treatment strategy. We report a patient with APL who achieved complete clinical and molecular remission after treatment with daunorubicin and ATRA. Three years later, she developed acute myeloid leukemia (AML), M2 subtype without any evidence of relapse of the APL clone. Karyotypic analysis showed a normal female karyotype. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3932606/ /pubmed/24604968 http://dx.doi.org/10.4103/0971-5851.125261 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sahoo, Ranjit Kumar
Kumar, Lalit
Kumar, Rajive
Sharma, Atul
Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics
title Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics
title_full Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics
title_fullStr Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics
title_full_unstemmed Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics
title_short Acute promyelocytic leukemia relapsing into acute myeloid leukemia-M2 with normal cytogenetics
title_sort acute promyelocytic leukemia relapsing into acute myeloid leukemia-m2 with normal cytogenetics
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932606/
https://www.ncbi.nlm.nih.gov/pubmed/24604968
http://dx.doi.org/10.4103/0971-5851.125261
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