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C-Reactive Protein: Clinical and Epidemiological Perspectives

An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascul...

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Autores principales: Salazar, Juan, Martínez, María Sofía, Chávez, Mervin, Toledo, Alexandra, Añez, Roberto, Torres, Yaquelín, Apruzzese, Vanessa, Silva, Carlos, Rojas, Joselyn, Bermúdez, Valmore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932642/
https://www.ncbi.nlm.nih.gov/pubmed/24653858
http://dx.doi.org/10.1155/2014/605810
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author Salazar, Juan
Martínez, María Sofía
Chávez, Mervin
Toledo, Alexandra
Añez, Roberto
Torres, Yaquelín
Apruzzese, Vanessa
Silva, Carlos
Rojas, Joselyn
Bermúdez, Valmore
author_facet Salazar, Juan
Martínez, María Sofía
Chávez, Mervin
Toledo, Alexandra
Añez, Roberto
Torres, Yaquelín
Apruzzese, Vanessa
Silva, Carlos
Rojas, Joselyn
Bermúdez, Valmore
author_sort Salazar, Juan
collection PubMed
description An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.
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spelling pubmed-39326422014-03-20 C-Reactive Protein: Clinical and Epidemiological Perspectives Salazar, Juan Martínez, María Sofía Chávez, Mervin Toledo, Alexandra Añez, Roberto Torres, Yaquelín Apruzzese, Vanessa Silva, Carlos Rojas, Joselyn Bermúdez, Valmore Cardiol Res Pract Review Article An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios. Hindawi Publishing Corporation 2014 2014-02-06 /pmc/articles/PMC3932642/ /pubmed/24653858 http://dx.doi.org/10.1155/2014/605810 Text en Copyright © 2014 Juan Salazar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Salazar, Juan
Martínez, María Sofía
Chávez, Mervin
Toledo, Alexandra
Añez, Roberto
Torres, Yaquelín
Apruzzese, Vanessa
Silva, Carlos
Rojas, Joselyn
Bermúdez, Valmore
C-Reactive Protein: Clinical and Epidemiological Perspectives
title C-Reactive Protein: Clinical and Epidemiological Perspectives
title_full C-Reactive Protein: Clinical and Epidemiological Perspectives
title_fullStr C-Reactive Protein: Clinical and Epidemiological Perspectives
title_full_unstemmed C-Reactive Protein: Clinical and Epidemiological Perspectives
title_short C-Reactive Protein: Clinical and Epidemiological Perspectives
title_sort c-reactive protein: clinical and epidemiological perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932642/
https://www.ncbi.nlm.nih.gov/pubmed/24653858
http://dx.doi.org/10.1155/2014/605810
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