GRowing an Epidermal Tumor

The glucocorticoid receptor (GR), a member of the nuclear hormone family of transcription factors, plays key physiological roles in many organs, including the skin. In this issue, Latorre et al. demonstrate that mice lacking GR in the epidermis exhibit increased vulnerability to chemical carcinogene...

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Detalles Bibliográficos
Autores principales: Bollag, Wendy B., Isales, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932965/
https://www.ncbi.nlm.nih.gov/pubmed/24216781
http://dx.doi.org/10.1038/jid.2013.350
Descripción
Sumario:The glucocorticoid receptor (GR), a member of the nuclear hormone family of transcription factors, plays key physiological roles in many organs, including the skin. In this issue, Latorre et al. demonstrate that mice lacking GR in the epidermis exhibit increased vulnerability to chemical carcinogenesis. Evidence supporting an involvement of GR signaling in physiological and pathophysiological processes in skin is discussed.

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