Mice with targeted disruption of spermidine/spermine N(1)-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. We have now generated SSAT knockout (SSAT-KO) mice, which confirmed our earlier results with SSAT deficient embryonic stem (ES) cells...

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Detalles Bibliográficos
Autores principales: Niiranen, Kirsi, Keinänen, Tuomo A, Pirinen, Eija, Heikkinen, Sami, Tusa, Maija, Fatrai, Szabolcs, Suppola, Suvikki, Pietilä, Marko, Uimari, Anne, Laakso, Markku, Alhonen, Leena, Jänne, Juhani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2006
Materias:
Epigenetic Review Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933077/
http://dx.doi.org/10.2755/jcmm010.004.02

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