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The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells

Cell secretio has come age, and a century old quest has been elegantly solved. We have come a long way since earlier observations of what appeared to be ‘fibrillar regions’ at teh cell plasama membrance, and electrophysological studies suggesting the presence of ‘fusion pores’ at the cell plasma mem...

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Detalles Bibliográficos
Autor principal: Jefingija, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933120/
https://www.ncbi.nlm.nih.gov/pubmed/16796798
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00398.x
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author Jefingija, S
author_facet Jefingija, S
author_sort Jefingija, S
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description Cell secretio has come age, and a century old quest has been elegantly solved. We have come a long way since earlier observations of what appeared to be ‘fibrillar regions’ at teh cell plasama membrance, and electrophysological studies suggesting the presence of ‘fusion pores’ at the cell plasma membrane where secretion occurs. Finally, the fusion pore or ‘porosome’ has been discovered, and its morpholgy and dynamics determined at nm resolution and in real time in live secretory cells. The porosome has been isolated, its omposition determined at nm resolution and in real time in live secretory cells. The porosme has been isolated, its composition determmined and it has been jkboth structurally and functionally reconsituted n artificial lipid membrance. The discoversy of the porosome as the univeral secretory machinery in cell and the discovery of the molecular mechaninsm of vesicular content expulsion during cell secretin have fially enabled a clear understanding of this important cellular process. This review outlines the fascinating and exciting joumey leding to the dicovery of the porosme, ultimately solving one of the most difficut, significant, and fundamental cellular process- cell seretion.
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spelling pubmed-39331202015-07-06 The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells Jefingija, S J Cell Mol Med Cell Secretion Review Series Cell secretio has come age, and a century old quest has been elegantly solved. We have come a long way since earlier observations of what appeared to be ‘fibrillar regions’ at teh cell plasama membrance, and electrophysological studies suggesting the presence of ‘fusion pores’ at the cell plasma membrane where secretion occurs. Finally, the fusion pore or ‘porosome’ has been discovered, and its morpholgy and dynamics determined at nm resolution and in real time in live secretory cells. The porosome has been isolated, its omposition determined at nm resolution and in real time in live secretory cells. The porosme has been isolated, its composition determmined and it has been jkboth structurally and functionally reconsituted n artificial lipid membrance. The discoversy of the porosome as the univeral secretory machinery in cell and the discovery of the molecular mechaninsm of vesicular content expulsion during cell secretin have fially enabled a clear understanding of this important cellular process. This review outlines the fascinating and exciting joumey leding to the dicovery of the porosme, ultimately solving one of the most difficut, significant, and fundamental cellular process- cell seretion. John Wiley & Sons, Ltd 2006-04 2007-05-01 /pmc/articles/PMC3933120/ /pubmed/16796798 http://dx.doi.org/10.1111/j.1582-4934.2006.tb00398.x Text en
spellingShingle Cell Secretion Review Series
Jefingija, S
The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
title The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
title_full The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
title_fullStr The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
title_full_unstemmed The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
title_short The sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
title_sort sory of cell secretion: events leading to the dicovery of the ‘porosome’- the universal secretory machinery in cells
topic Cell Secretion Review Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933120/
https://www.ncbi.nlm.nih.gov/pubmed/16796798
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00398.x
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