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Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933136/ https://www.ncbi.nlm.nih.gov/pubmed/16796814 http://dx.doi.org/10.1111/j.1582-4934.2006.tb00414.x |
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author | Zacharakis, N Tone, P Flordellis, CS Maragoudakis, ME Tsopanoglou, NE |
author_facet | Zacharakis, N Tone, P Flordellis, CS Maragoudakis, ME Tsopanoglou, NE |
author_sort | Zacharakis, N |
collection | PubMed |
description | Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, methylene blue inhibited angiogenesis in a concentration-dependent manner. In addition, when methylene blue was combined with sodium nitroprusside, a spontaneous generator of nitric oxide, an inhibition of angiogenesis was evident which was comparable with that observed by the application of methylene blue alone. Sodium nitroprusside, alone, caused a significant inhibition in basal angiogenesis. These results provide evidence that methylene blue inhibits angiogenesis independently of nitric oxide pathway and suggest that methylene blue may be useful for treating angiogenesis-dependent human diseases. |
format | Online Article Text |
id | pubmed-3933136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39331362015-07-06 Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism Zacharakis, N Tone, P Flordellis, CS Maragoudakis, ME Tsopanoglou, NE J Cell Mol Med Phenomenin Review Series Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, methylene blue inhibited angiogenesis in a concentration-dependent manner. In addition, when methylene blue was combined with sodium nitroprusside, a spontaneous generator of nitric oxide, an inhibition of angiogenesis was evident which was comparable with that observed by the application of methylene blue alone. Sodium nitroprusside, alone, caused a significant inhibition in basal angiogenesis. These results provide evidence that methylene blue inhibits angiogenesis independently of nitric oxide pathway and suggest that methylene blue may be useful for treating angiogenesis-dependent human diseases. John Wiley & Sons, Ltd 2006-04 2007-05-01 /pmc/articles/PMC3933136/ /pubmed/16796814 http://dx.doi.org/10.1111/j.1582-4934.2006.tb00414.x Text en |
spellingShingle | Phenomenin Review Series Zacharakis, N Tone, P Flordellis, CS Maragoudakis, ME Tsopanoglou, NE Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
title | Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
title_full | Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
title_fullStr | Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
title_full_unstemmed | Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
title_short | Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
title_sort | methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism |
topic | Phenomenin Review Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933136/ https://www.ncbi.nlm.nih.gov/pubmed/16796814 http://dx.doi.org/10.1111/j.1582-4934.2006.tb00414.x |
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