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Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism

Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well c...

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Autores principales: Zacharakis, N, Tone, P, Flordellis, CS, Maragoudakis, ME, Tsopanoglou, NE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933136/
https://www.ncbi.nlm.nih.gov/pubmed/16796814
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00414.x
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author Zacharakis, N
Tone, P
Flordellis, CS
Maragoudakis, ME
Tsopanoglou, NE
author_facet Zacharakis, N
Tone, P
Flordellis, CS
Maragoudakis, ME
Tsopanoglou, NE
author_sort Zacharakis, N
collection PubMed
description Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, methylene blue inhibited angiogenesis in a concentration-dependent manner. In addition, when methylene blue was combined with sodium nitroprusside, a spontaneous generator of nitric oxide, an inhibition of angiogenesis was evident which was comparable with that observed by the application of methylene blue alone. Sodium nitroprusside, alone, caused a significant inhibition in basal angiogenesis. These results provide evidence that methylene blue inhibits angiogenesis independently of nitric oxide pathway and suggest that methylene blue may be useful for treating angiogenesis-dependent human diseases.
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spelling pubmed-39331362015-07-06 Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism Zacharakis, N Tone, P Flordellis, CS Maragoudakis, ME Tsopanoglou, NE J Cell Mol Med Phenomenin Review Series Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, methylene blue inhibited angiogenesis in a concentration-dependent manner. In addition, when methylene blue was combined with sodium nitroprusside, a spontaneous generator of nitric oxide, an inhibition of angiogenesis was evident which was comparable with that observed by the application of methylene blue alone. Sodium nitroprusside, alone, caused a significant inhibition in basal angiogenesis. These results provide evidence that methylene blue inhibits angiogenesis independently of nitric oxide pathway and suggest that methylene blue may be useful for treating angiogenesis-dependent human diseases. John Wiley & Sons, Ltd 2006-04 2007-05-01 /pmc/articles/PMC3933136/ /pubmed/16796814 http://dx.doi.org/10.1111/j.1582-4934.2006.tb00414.x Text en
spellingShingle Phenomenin Review Series
Zacharakis, N
Tone, P
Flordellis, CS
Maragoudakis, ME
Tsopanoglou, NE
Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
title Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
title_full Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
title_fullStr Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
title_full_unstemmed Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
title_short Methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
title_sort methylene blue inhibits angiogenesis in chick chorioallontic membrane through a nitric oxide-independent mechanism
topic Phenomenin Review Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933136/
https://www.ncbi.nlm.nih.gov/pubmed/16796814
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00414.x
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