The G(516)T CYP2B6 Germline Polymorphism Affects the Risk of Acute Myeloid Leukemia and Is Associated with Specific Chromosomal Abnormalities

The etiology of acute myeloid leukemia (AML) underlies the influence of genetic variants in candidate genes. The CYP2B6 enzyme detoxifies many genotoxic xenobiotics, protecting cells from oxidative damage. The CYP2B6 gene is subjected to a single-nucleotide polymorphism (G(516)T) with heterozygotes...

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Detalles Bibliográficos
Autores principales: Daraki, Aggeliki, Zachaki, Sophia, Koromila, Theodora, Diamantopoulou, Paraskevi, Pantelias, Gabriel E., Sambani, Constantina, Aleporou, Vasiliki, Kollia, Panagoula, Manola, Kalliopi N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933334/
https://www.ncbi.nlm.nih.gov/pubmed/24586425
http://dx.doi.org/10.1371/journal.pone.0088879

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