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Catalytic Signature of a Heat-Stable, Chimeric Human Alkaline Phosphatase with Therapeutic Potential

Recombinant alkaline phosphatases are becoming promising protein therapeutics to prevent skeletal mineralization defects, inflammatory bowel diseases, and treat acute kidney injury. By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placen...

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Detalles Bibliográficos
Autores principales:	Kiffer-Moreira, Tina, Sheen, Campbell R., Gasque, Kellen Cristina da Silva, Bolean, Mayte, Ciancaglini, Pietro, van Elsas, Andrea, Hoylaerts, Marc F., Millán, José Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933536/ https://www.ncbi.nlm.nih.gov/pubmed/24586729 http://dx.doi.org/10.1371/journal.pone.0089374

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