Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway

INTRODUCTION: There is currently no curative treatment for melanoma once the disease spreads beyond the original site. Although activation of the PI3K/Akt pathway resulting from genetic mutations and epigenetic deregulation of its major regulators is known to cause resistance of melanoma to therapeu...

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Detalles Bibliográficos
Autores principales: Chi, Mengna, Ye, Yan, Zhang, Xu Dong, Chen, Jiezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933667/
https://www.ncbi.nlm.nih.gov/pubmed/24600206
http://dx.doi.org/10.2147/DDDT.S53568

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