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Ipilimumab in the treatment of metastatic melanoma: management of adverse events

Recently, “ipilimumab,” an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. “CTLA-4” is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is abl...

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Detalles Bibliográficos
Autores principales:	Della Vittoria Scarpati, Giuseppina, Fusciello, Celeste, Perri, Francesco, Sabbatino, Francesco, Ferrone, Soldano, Carlomagno, Chiara, Pepe, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933725/ https://www.ncbi.nlm.nih.gov/pubmed/24570590 http://dx.doi.org/10.2147/OTT.S57335

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