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Augmented mast cell infiltration and microvessel density in prostate cancer
AIM OF THE STUDY: Recent investigations have taken into account the role of mast cells in prostate cancer formation, analyzing their dual functions (as tumour growth promoters and tumour growth inhibitors). The aim of our study was to compare mast cell infiltration and microvessel density in prostat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934053/ https://www.ncbi.nlm.nih.gov/pubmed/24592126 http://dx.doi.org/10.5114/wo.2013.37220 |
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author | Stawerski, Paweł Wagrowska-Danilewicz, Małgorzata Stasikowska-Kanicka, Olga Tuka, Elżbieta Danilewicz, Marian |
author_facet | Stawerski, Paweł Wagrowska-Danilewicz, Małgorzata Stasikowska-Kanicka, Olga Tuka, Elżbieta Danilewicz, Marian |
author_sort | Stawerski, Paweł |
collection | PubMed |
description | AIM OF THE STUDY: Recent investigations have taken into account the role of mast cells in prostate cancer formation, analyzing their dual functions (as tumour growth promoters and tumour growth inhibitors). The aim of our study was to compare mast cell infiltration and microvessel density in prostate cancer and in benign prostate hyperplasia. We also attempted to find possible relationships among mast cell infiltration and microvessel density, Gleason score, as well as serum levels of prostate-specific antigen (PSA). MATERIAL AND METHODS: The investigation was confined to evaluations of material from prostate needle biopsies, carried out in 26 patients with prostate cancer, and of 14 specimens diagnosed as benign hyperplasia. The numbers of tryptase positive mast cells and CD34 positive vessels were determined using a computer image analysis system. In the patients with prostate cancer, both mast cell infiltrates and microvessel density were significantly increased, as compared to the control patients. RESULTS: Significant positive correlations were identified between the mean numbers of mast cells and microvessel densities, both in the prostate cancer group and in the control group. Moreover, significant positive correlations were observed between Gleason score on one hand and the number of mast cells and microvessel density on the other. The correlations between PSA serum levels and both mast cell infiltration and microvessel density were positive, but not in a statistically significant way. CONCLUSIONS: The reported investigations may support the assumption of mast cell promoter function in prostate cancer development, whereas no evidence was found for their opposite |
format | Online Article Text |
id | pubmed-3934053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-39340532014-03-03 Augmented mast cell infiltration and microvessel density in prostate cancer Stawerski, Paweł Wagrowska-Danilewicz, Małgorzata Stasikowska-Kanicka, Olga Tuka, Elżbieta Danilewicz, Marian Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: Recent investigations have taken into account the role of mast cells in prostate cancer formation, analyzing their dual functions (as tumour growth promoters and tumour growth inhibitors). The aim of our study was to compare mast cell infiltration and microvessel density in prostate cancer and in benign prostate hyperplasia. We also attempted to find possible relationships among mast cell infiltration and microvessel density, Gleason score, as well as serum levels of prostate-specific antigen (PSA). MATERIAL AND METHODS: The investigation was confined to evaluations of material from prostate needle biopsies, carried out in 26 patients with prostate cancer, and of 14 specimens diagnosed as benign hyperplasia. The numbers of tryptase positive mast cells and CD34 positive vessels were determined using a computer image analysis system. In the patients with prostate cancer, both mast cell infiltrates and microvessel density were significantly increased, as compared to the control patients. RESULTS: Significant positive correlations were identified between the mean numbers of mast cells and microvessel densities, both in the prostate cancer group and in the control group. Moreover, significant positive correlations were observed between Gleason score on one hand and the number of mast cells and microvessel density on the other. The correlations between PSA serum levels and both mast cell infiltration and microvessel density were positive, but not in a statistically significant way. CONCLUSIONS: The reported investigations may support the assumption of mast cell promoter function in prostate cancer development, whereas no evidence was found for their opposite Termedia Publishing House 2013-10-07 2013 /pmc/articles/PMC3934053/ /pubmed/24592126 http://dx.doi.org/10.5114/wo.2013.37220 Text en Copyright © 2013 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Stawerski, Paweł Wagrowska-Danilewicz, Małgorzata Stasikowska-Kanicka, Olga Tuka, Elżbieta Danilewicz, Marian Augmented mast cell infiltration and microvessel density in prostate cancer |
title | Augmented mast cell infiltration and microvessel density in prostate cancer |
title_full | Augmented mast cell infiltration and microvessel density in prostate cancer |
title_fullStr | Augmented mast cell infiltration and microvessel density in prostate cancer |
title_full_unstemmed | Augmented mast cell infiltration and microvessel density in prostate cancer |
title_short | Augmented mast cell infiltration and microvessel density in prostate cancer |
title_sort | augmented mast cell infiltration and microvessel density in prostate cancer |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934053/ https://www.ncbi.nlm.nih.gov/pubmed/24592126 http://dx.doi.org/10.5114/wo.2013.37220 |
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