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The ARF tumor suppressor controls Drosha translation to prevent Ras-driven transformation
ARF is a multifunctional tumor suppressor that acts as both a sensor of oncogenic stimuli and as a key regulator of ribosome biogenesis. Recently, our group established the DEAD-box RNA helicase and microRNA (miRNA) microprocessor accessory subunit, DDX5, as a critical target of basal ARF function....
Autores principales: | Kuchenreuther, Michael J., Weber, Jason D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934099/ https://www.ncbi.nlm.nih.gov/pubmed/23318441 http://dx.doi.org/10.1038/onc.2012.601 |
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