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Treating Cloned Embryos, But Not Donor Cells, with 5-aza-2’-deoxycytidine Enhances the Developmental Competence of Porcine Cloned Embryos

The efficiency of cloning by somatic cell nuclear transfer (SCNT) has remained low. In most cloned embryos, epigenetic reprogramming is incomplete, and usually the genome is hypermethylated. The DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-aza-dC) could improve the developmental competence of...

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Detalles Bibliográficos
Autores principales:	HUAN, Yan Jun, ZHU, Jiang, XIE, Bing Teng, WANG, Jian Yu, LIU, Shi Chao, ZHOU, Yang, KONG, Qing Ran, HE, Hong Bin, LIU, Zhong Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Society for Reproduction and Development 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934119/ https://www.ncbi.nlm.nih.gov/pubmed/23748715 http://dx.doi.org/10.1262/jrd.2013-026

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