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Valproic Acid Treatment from the 4-cell Stage Improves Oct4 Expression and Nuclear Distribution of Histone H3K27me3 in Mouse Cloned Blastocysts

We examined effects of treatment with valproic acid (0, 0.2, 1 or 2 mM, VPA), an inhibitor of class I and IIa histone deacetylases (HDACs), of mouse somatic cell nuclear transfer (SCNT) embryos for 24 h from 48 h (4-cell stage), 24 h (2-cell stage) or immediately after oocyte activation on blastocys...

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Detalles Bibliográficos
Autores principales:	ISAJI, Yuuki, MURATA, Moeko, TAKAGUCHI, Naoya, MUKAI, Toshita, TAJIMA, Yosuke, IMAI, Hiroshi, YAMADA, Masayasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Society for Reproduction and Development 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934201/ https://www.ncbi.nlm.nih.gov/pubmed/23337102 http://dx.doi.org/10.1262/jrd.2012-156

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