Cargando…

Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia

Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic chole...

Descripción completa

Detalles Bibliográficos
Autores principales: Vlachaki, Efthymia, Andreadis, Panagiotis, Neokleous, Nikolaos, Agapidou, Aleka, Vetsiou, Evaggelia, Katsinelos, Panagiotis, Boura, Panagiota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934305/
https://www.ncbi.nlm.nih.gov/pubmed/24660076
http://dx.doi.org/10.1155/2014/213631
_version_ 1782305050019758080
author Vlachaki, Efthymia
Andreadis, Panagiotis
Neokleous, Nikolaos
Agapidou, Aleka
Vetsiou, Evaggelia
Katsinelos, Panagiotis
Boura, Panagiota
author_facet Vlachaki, Efthymia
Andreadis, Panagiotis
Neokleous, Nikolaos
Agapidou, Aleka
Vetsiou, Evaggelia
Katsinelos, Panagiotis
Boura, Panagiota
author_sort Vlachaki, Efthymia
collection PubMed
description Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β (+)thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β (+)thal.
format Online
Article
Text
id pubmed-3934305
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39343052014-03-23 Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia Vlachaki, Efthymia Andreadis, Panagiotis Neokleous, Nikolaos Agapidou, Aleka Vetsiou, Evaggelia Katsinelos, Panagiotis Boura, Panagiota Case Rep Hematol Case Report Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β (+)thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β (+)thal. Hindawi Publishing Corporation 2014 2014-02-09 /pmc/articles/PMC3934305/ /pubmed/24660076 http://dx.doi.org/10.1155/2014/213631 Text en Copyright © 2014 Efthymia Vlachaki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vlachaki, Efthymia
Andreadis, Panagiotis
Neokleous, Nikolaos
Agapidou, Aleka
Vetsiou, Evaggelia
Katsinelos, Panagiotis
Boura, Panagiota
Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
title Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
title_full Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
title_fullStr Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
title_full_unstemmed Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
title_short Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
title_sort successful outcome of chronic intrahepatic cholestasis in an adult patient with sickle cell/β (+) thalassemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934305/
https://www.ncbi.nlm.nih.gov/pubmed/24660076
http://dx.doi.org/10.1155/2014/213631
work_keys_str_mv AT vlachakiefthymia successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia
AT andreadispanagiotis successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia
AT neokleousnikolaos successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia
AT agapidoualeka successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia
AT vetsiouevaggelia successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia
AT katsinelospanagiotis successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia
AT bourapanagiota successfuloutcomeofchronicintrahepaticcholestasisinanadultpatientwithsicklecellbthalassemia