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Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia
Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic chole...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934305/ https://www.ncbi.nlm.nih.gov/pubmed/24660076 http://dx.doi.org/10.1155/2014/213631 |
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author | Vlachaki, Efthymia Andreadis, Panagiotis Neokleous, Nikolaos Agapidou, Aleka Vetsiou, Evaggelia Katsinelos, Panagiotis Boura, Panagiota |
author_facet | Vlachaki, Efthymia Andreadis, Panagiotis Neokleous, Nikolaos Agapidou, Aleka Vetsiou, Evaggelia Katsinelos, Panagiotis Boura, Panagiota |
author_sort | Vlachaki, Efthymia |
collection | PubMed |
description | Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β (+)thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β (+)thal. |
format | Online Article Text |
id | pubmed-3934305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39343052014-03-23 Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia Vlachaki, Efthymia Andreadis, Panagiotis Neokleous, Nikolaos Agapidou, Aleka Vetsiou, Evaggelia Katsinelos, Panagiotis Boura, Panagiota Case Rep Hematol Case Report Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β (+)thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β (+)thal. Hindawi Publishing Corporation 2014 2014-02-09 /pmc/articles/PMC3934305/ /pubmed/24660076 http://dx.doi.org/10.1155/2014/213631 Text en Copyright © 2014 Efthymia Vlachaki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Vlachaki, Efthymia Andreadis, Panagiotis Neokleous, Nikolaos Agapidou, Aleka Vetsiou, Evaggelia Katsinelos, Panagiotis Boura, Panagiota Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β (+) Thalassemia |
title | Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β
(+) Thalassemia |
title_full | Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β
(+) Thalassemia |
title_fullStr | Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β
(+) Thalassemia |
title_full_unstemmed | Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β
(+) Thalassemia |
title_short | Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β
(+) Thalassemia |
title_sort | successful outcome of chronic intrahepatic cholestasis in an adult patient with sickle cell/β
(+) thalassemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934305/ https://www.ncbi.nlm.nih.gov/pubmed/24660076 http://dx.doi.org/10.1155/2014/213631 |
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