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Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation, the severity of which is assessed using forced expiratory volume in 1 sec (FEV(1), % predicted). Cohort studies have confirmed that COPD patients with similar levels of airflow limitation showed marked he...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934315/ https://www.ncbi.nlm.nih.gov/pubmed/24683548 http://dx.doi.org/10.1155/2014/420134 |
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author | Burgel, Pierre-Régis Paillasseur, Jean-Louis Roche, Nicolas |
author_facet | Burgel, Pierre-Régis Paillasseur, Jean-Louis Roche, Nicolas |
author_sort | Burgel, Pierre-Régis |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation, the severity of which is assessed using forced expiratory volume in 1 sec (FEV(1), % predicted). Cohort studies have confirmed that COPD patients with similar levels of airflow limitation showed marked heterogeneity in clinical manifestations and outcomes. Chronic coexisting diseases, also called comorbidities, are highly prevalent in COPD patients and likely contribute to this heterogeneity. In recent years, investigators have used innovative statistical methods (e.g., cluster analyses) to examine the hypothesis that subgroups of COPD patients sharing clinically relevant characteristics (phenotypes) can be identified. The objectives of the present paper are to review recent studies that have used cluster analyses for defining phenotypes in observational cohorts of COPD patients. Strengths and weaknesses of these statistical approaches are briefly described. Description of the phenotypes that were reasonably reproducible across studies and received prospective validation in at least one study is provided, with a special focus on differences in age and comorbidities (including cardiovascular diseases). Finally, gaps in current knowledge are described, leading to proposals for future studies. |
format | Online Article Text |
id | pubmed-3934315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39343152014-03-30 Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities Burgel, Pierre-Régis Paillasseur, Jean-Louis Roche, Nicolas Biomed Res Int Review Article Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation, the severity of which is assessed using forced expiratory volume in 1 sec (FEV(1), % predicted). Cohort studies have confirmed that COPD patients with similar levels of airflow limitation showed marked heterogeneity in clinical manifestations and outcomes. Chronic coexisting diseases, also called comorbidities, are highly prevalent in COPD patients and likely contribute to this heterogeneity. In recent years, investigators have used innovative statistical methods (e.g., cluster analyses) to examine the hypothesis that subgroups of COPD patients sharing clinically relevant characteristics (phenotypes) can be identified. The objectives of the present paper are to review recent studies that have used cluster analyses for defining phenotypes in observational cohorts of COPD patients. Strengths and weaknesses of these statistical approaches are briefly described. Description of the phenotypes that were reasonably reproducible across studies and received prospective validation in at least one study is provided, with a special focus on differences in age and comorbidities (including cardiovascular diseases). Finally, gaps in current knowledge are described, leading to proposals for future studies. Hindawi Publishing Corporation 2014 2014-02-10 /pmc/articles/PMC3934315/ /pubmed/24683548 http://dx.doi.org/10.1155/2014/420134 Text en Copyright © 2014 Pierre-Régis Burgel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Burgel, Pierre-Régis Paillasseur, Jean-Louis Roche, Nicolas Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities |
title | Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities |
title_full | Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities |
title_fullStr | Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities |
title_full_unstemmed | Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities |
title_short | Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities |
title_sort | identification of clinical phenotypes using cluster analyses in copd patients with multiple comorbidities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934315/ https://www.ncbi.nlm.nih.gov/pubmed/24683548 http://dx.doi.org/10.1155/2014/420134 |
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